Isolation and structural elucidation of β-tocopherol derivatives from Dryopteris crassirhizoma
Isolation and structural elucidation of β-tocopherol derivatives from Dryopteris crassirhizoma
复制标题
粗鳞毛蕨中 β-生育酚衍生物的分离和结构解析
DOI：
10.1016/j.indcrop.2021.114010
复制
发表时间：
2021-11
影响因子：
5.9
通讯作者：
Guocai Wang
中科院分区：
文献类型：
--
作者：
Nenghua Chen;Wen Li;Jihui Zhang;Weibin Xu;Zhongnan Wu;Yaolan Li;Yubo Zhang;Qingwen Zhang;Guocai Wang
粗茎鳞毛蕨（Dryopteris crassirhizomaNakai）为鳞毛蕨科（Dryopteridaceae）的一种粗茎木本蕨类植物，主要分布于我国北方和东北地区。它在园艺和医药应用方面具有重要价值。从粗茎鳞毛蕨（Dryopteriscrassirhizoma）根茎中分离得到5个β-生育酚衍生物，即粗茎鳞毛蕨醇（drycrassperols）A-E（1-5），具有3种骨架结构。化合物1 - 2的基本结构是苯酚基序通过吡喃环与植基型二萜稠合，化合物3 - 4具有前所未有的四环体系，其中4-甲基环己酮被引入1的基本单元。有趣的是，化合物5是一个新的二聚体，由两个单体通过吡喃环形成一个五环系统。这些结构通过综合的光谱数据和量子化学电子圆二色性（ECD）计算进行了阐明。重要的是，化合物1表现出与阳性对照利巴韦林相当的抗呼吸道合胞病毒活性，IC 50值为6.50 ± 1.25 μM。本研究表明，D.β-生育酚衍生物在医药工业中具有新的潜在应用。
Dryopteris crassirhizomaNakai (Dryopteridaceae), a thick-stemmed wood fern, is a semi-evergreen plant mainly distributed in North and Northeast China. It is of great value in horticultural and medicinal applications. In this study, five β-tocopherol derivatives, drycrasspherols A–E (1–5), with three kinds of skeletons, were isolated from the rhizomes ofDryopteris crassirhizoma. Compounds1–2represent the basic architecture featuring a phenol motif fused with the phytyl-type diterpene via a pyran ring, compounds3–4possess an unprecedented tetracyclic system in which a 4-methylcyclohexanone is incorporated into the base unit of1. Interestingly, compound5is a novel dimer constructed from two monomers via a pyran ring to form a pentacyclic system. These structures were elucidated by comprehensive spectroscopic data and quantum chemical electronic circular dichroism (ECD) calculations. Importantly, compound1exhibited the comparable anti-respiratory syncytial virus activity with an IC50value of 6.50 ± 1.25 μM to the positive control ribavirin. This study suggested the rhizomes ofD. crassirhizomaas well as the β-tocopherol derivatives had new potential applications in pharmaceutical industry.
登录
查看更多内容
影响因子：
7.4
作者：
Jiang, Qing
通讯作者：
Jiang, Qing
影响因子：
1.7
作者：
Van Cong Pham;Kim, Okhwa;Kim, Jeong Ah
通讯作者：
Kim, Jeong Ah
影响因子：
4.3
作者：
Lodge, JK
通讯作者：
Lodge, JK
影响因子：
16.6
作者：
Liu, Kegang;Chougnet, Antoinette;Woggon, Wolf-D.
通讯作者：
Woggon, Wolf-D.
DOI：
10.3390/molecules26010122
发表时间：
2020-12-29
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Yuk HJ;Kim JY;Sung YY;Kim DS
通讯作者：
Kim DS