Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.
Age-related ultrastructural changes in the lateral cortex of the inferior colliculus.
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DOI：
10.1016/j.neurobiolaging.2022.08.007
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发表时间：
2022-12
影响因子：
4.2
通讯作者：
Mellott, Jeffrey G.
中科院分区：
文献类型：
--
作者：
Mafi, Amir M.;Tokar, Nick;Russ, Matthew G.;Barat, Oren;Mellott, Jeffrey G.
时间精确度是下丘(IC)声音和语音处理的关键组成部分，依赖于抑制和兴奋的平衡，这种平衡随着年龄的增长而下降。衰老过程中兴奋性-抑制性平衡被破坏的原因尚不清楚，但突触的变化可能是一个候选因素。我们试图确定突触变化是否发生在IC的外侧皮质(IClc)，这是一个处理丘脑、内脏、躯体感觉和下行听觉输入的多模式核。用电子显微镜技术对年轻、中年和老年的Fisher Brown挪威大鼠进行研究，我们的结果表明，中年时突触的丢失很少，但在老年时突触的丢失显著(~28%)。然而，在中年，GABA能突触对GABA能树突的靶向性增加，兴奋性突触(主要针对GABA阴性树突)的活动区延长。这些突触变化可能导致中年时ICLC兴奋性的净增加。因此，老年ICLC兴奋性-抑制性平衡的破坏可能是由于中年开始的突触变化所致。
Temporal precision, a key component of sound and speech processing in the inferior colliculus (IC), depends on a balance of inhibition and excitation, and this balance degrades during aging. The cause of disrupted excitatory-inhibitory balance in aging is unknown, however changes at the synapse are a likely candidate. We sought to determine whether synaptic changes occur in the lateral cortex of the IC (IClc), a multimodal nucleus that processes lemniscal, intrinsic, somatosensory and descending auditory input. Using electron microscopic techniques across young, middle age and old Fisher Brown Norway rats, our results demonstrate minimal loss of synapses in middle age, but significant (~28%) loss during old age. However, in middle age, targeting of GABAergic dendrites by GABAergic synapses is increased and the active zones of excitatory synapses (that predominantly target GABA-negative dendrites) are lengthened. These synaptic changes likely result in a net increase of excitation in the IClc during middle age. Thus, disruption of excitatory-inhibitory balance in the aging IClc may be due to synaptic changes that begin in middle age.
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影响因子：
4.8
作者：
Dixon CL;Sah P;Keramidas A;Lynch JW;Durisic N
通讯作者：
Durisic N
影响因子：
4.2
作者：
Cai R;Montgomery SC;Graves KA;Caspary DM;Cox BC
通讯作者：
Cox BC
影响因子：
2.5
作者：
Coomes, DL;Bickford, ME;Schofield, BR
通讯作者：
Schofield, BR
DOI：
10.1007/bf00319050
发表时间：
1985-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
FAYELUND, H;OSEN, KK
通讯作者：
OSEN, KK
影响因子：
3.9
作者：
CASPARY, DM;MILBRANDT, JC;HELFERT, RH
通讯作者：
HELFERT, RH