Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit.
Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit.
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DOI：
10.3892/etm.2018.5775
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发表时间：
2018-03
影响因子：
2.7
通讯作者：
Zhang ZD
中科院分区：
文献类型：
--
作者：
Liu QY;Han F;Pan LP;Jia HY;Li Q;Zhang ZD
由结核分枝杆菌引起的肺结核仍然是一个全球性问题。炎症反应是重症监护病房（ICU）肺结核患者的主要特征。本研究的目的是探讨炎性细胞和因子对ICU肺结核患者的临床意义。本研究共纳入124例ICU肺结核患者。通过检测ICU肺结核患者血清中炎性细胞和炎性因子的变化，探讨ICU肺结核患者的炎性反应。结果表明，与健康对照组相比，ICU肺结核患者血清淋巴细胞、浆细胞、粒细胞和单核细胞水平升高。ICU肺结核患者血清炎症因子IL-1、IL-6、IL-10、IL-12、IL-4水平升高。肺结核患者血浆IL-2、IL-15和IFN-γ水平低于健康对照组。肺结核患者血清中高迁移率族蛋白B1的表达水平明显高于健康对照组。值得注意的是，在肺结核患者中观察到T辅助细胞（Th）1/Th 2细胞因子的失衡。肺结核由M.结核还上调hPMCs中基质金属蛋白酶（MMP）-1和MMP-9的表达。总之，这些结果表明，炎症反应和炎症因子与肺结核的进展相关，提示抑制炎症反应和炎症因子可能有利于ICU肺结核患者的治疗。
Pulmonary tuberculosis caused by Mycobacterium tuberculosis remains a global problem. Inflammatory responses are the primary characteristics of patients with pulmonary tuberculosis in intensive care units (ICU). The aim of the present study was to investigate the clinical importance of inflammatory cells and factors for patients with pulmonary tuberculosis in ICU. A total of 124 patients with pulmonary tuberculosis in ICU were recruited for the present study. The inflammatory responses in patients with pulmonary tuberculosis in ICU were examined by changes in inflammatory cells and factors in the serum. The results indicated that serum levels of lymphocytes, plasma cells, granulocytes and monocytes were increased in patients with pulmonary tuberculosis in ICU compared with healthy controls. The serum levels of inflammatory factors interleukin (IL)-1, IL-6, IL-10, IL-12, and IL-4 were upregulated in patients with pulmonary tuberculosis in ICU. Lower plasma concentrations of IL-2, IL-15 and interferon-γ were detected in patients with pulmonary tuberculosis compared with healthy controls. It was demonstrated that high mobility group box-1 protein expression levels were higher in the serum of patients with pulmonary tuberculosis compared with healthy controls. Notably, an imbalance of T-helper cell (Th)1/Th2 cytokines was observed in patients with pulmonary tuberculosis. Pulmonary tuberculosis caused by M. tuberculosis also upregulated expression of matrix metalloproteinase (MMP)-1 and MMP-9 in hPMCs. In conclusion, these outcomes demonstrated that inflammatory responses and inflammatory factors are associated with the progression of pulmonary tuberculosis, suggesting that inhibition of inflammatory responses and inflammatory factors may be beneficial for the treatment of patients with pulmonary tuberculosis in ICU.
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影响因子：
--
作者：
Azfar, Shah Farhan;Islam, Najmul
通讯作者：
Islam, Najmul
影响因子：
2.3
作者：
Gunluoglu, Gulsah;Yazar, Esra Ertan;Altin, Sedat
通讯作者：
Altin, Sedat
影响因子：
1.6
作者：
Mahmoud, Ebrahim S.;Baharoon, Salim A.;Al-Jahdali, Hamdan
通讯作者：
Al-Jahdali, Hamdan
影响因子：
3.7
作者：
Georghiou SB;Magana M;Garfein RS;Catanzaro DG;Catanzaro A;Rodwell TC
通讯作者：
Rodwell TC
DOI：
10.1016/j.str.2012.09.016
发表时间：
2012-12-05
期刊：
Structure (London, England : 1993)
影响因子：
--
作者：
Erdemli SB;Gupta R;Bishai WR;Lamichhane G;Amzel LM;Bianchet MA
通讯作者：
Bianchet MA