Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.
Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.
复制标题
进行性视网膜变性会增加光刺激的皮质反应潜伏期，而不是电刺激的潜伏期。
DOI：
10.1167/tvst.11.4.19
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发表时间：
2022-04-01
影响因子：
3
通讯作者：
Weiland, James D.
中科院分区：
文献类型：
--
作者：
Koo, Beomseo;Weiland, James D.
关键词：
众所周知，失明后大脑会在功能和结构上发生变化，但恢复皮质输入对大脑功能的影响却知之甚少。在这里，我们提出了一项初步研究，以观察在临床相关的视网膜色素变性动物模型中，视觉和电诱发皮质电位随年龄的变化。我们在视网膜变性动物模型LE-P23H-1上记录了光(视觉诱发电位[VEP])或角膜电刺激(电诱发反应[EER])诱发的脑电位。我们使用线性混合模型来检验年龄对P120、P180和P360年龄组VEP和EER潜伏期和波幅的影响。分析不同动物年龄的视觉诱发电位N1、P1和N2的潜伏期和波幅。对于1 HzVEP，N1潜伏期随年龄的增加而显著延长(斜率=0.053±0.020 ms/d，P<0.01)。对于10 HzVEP，N1、P1和N2潜伏期随着动物年龄的增加而显著增加(斜率分别为0.104±0.011、0.135±0.011、0.087±0.023毫秒/天和P<；0.001)。相反，EER潜伏期不随年龄变化。VEP和EER的信号幅度不随年龄变化。尽管P23H大鼠视网膜持续变性，但视网膜电刺激诱发的皮质电位并未减弱。这些发现表明，视网膜生物电子治疗色素性视网膜炎将始终如一地激活皮质，尽管视网膜外层变性存在差异。视网膜刺激的临床研究应将不同的视网膜色素变性基因型别作为实验设计的一部分。
The brain is known to change functionally and structurally in response to blindness, but less is known about the effects of restoration of cortical input on brain function. Here, we present a preliminary study to observe alterations in visual and electrical evoked cortical potentials as a function of age in a clinically relevant animal model of retinitis pigmentosa. We recorded brain potentials elicited by light (visual evoked potentials [VEPs]) or corneal electrical stimulation (electrical evoked response [EER]) in retinal degenerate animal model LE-P23H-1. We used a linear mixed model to examine the effects of age on latency and amplitude of VEP and EER age groups P120, P180, and P360. VEP N1, P1, and N2 latency and amplitude were analyzed across animal age. For 1 Hz VEP, N1 latency increased significantly with animal age (slope = 0.053 ± 0.020 ms/day, P < 0.01). For 10 Hz VEP, N1, P1, and N2 latency increased significantly with animal age (slope = 0.104 ± 0.011, 0.135 ± 0.011, 0.087 ± 0.023 ms/day, and P < 0.001 for all VEP peaks). Conversely, EER latency did not change with age. Signal amplitude of VEP or EER did not change with age. Cortical potentials evoked by electrical stimulation of the retina do not diminish in spite of continued retinal degeneration in P23H rats. These findings suggest that retinal bioelectronic treatments of retinitis pigmentosa will activate cortex consistently despite variations in outer retinal degeneration. Clinical studies of retinal stimulation should consider varying retinitis pigmentosa genotypes as part of the experimental design.
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影响因子：
3.7
作者：
Monai N;Yamauchi K;Tanabu R;Gonome T;Ishiguro SI;Nakazawa M
通讯作者：
Nakazawa M
影响因子：
41.2
作者：
Maya-Vetencourt JF;Ghezzi D;Antognazza MR;Colombo E;Mete M;Feyen P;Desii A;Buschiazzo A;Di Paolo M;Di Marco S;Ticconi F;Emionite L;Shmal D;Marini C;Donelli I;Freddi G;Maccarone R;Bisti S;Sambuceti G;Pertile G;Lanzani G;Benfenati F
通讯作者：
Benfenati F
影响因子：
3.4
作者：
Hanif AM;Kim MK;Thomas JG;Ciavatta VT;Chrenek M;Hetling JR;Pardue MT
通讯作者：
Pardue MT
啮齿动物眼的光谱域光学相干断层扫描：使用信号平均和组织学比较，突出显示外视网膜的层。
影响因子：
3.7
作者：
Berger A;Cavallero S;Dominguez E;Barbe P;Simonutti M;Sahel JA;Sennlaub F;Raoul W;Paques M;Bemelmans AP
通讯作者：
Bemelmans AP
影响因子：
3.4
作者：
LaVail MM;Nishikawa S;Steinberg RH;Naash MI;Duncan JL;Trautmann N;Matthes MT;Yasumura D;Lau-Villacorta C;Chen J;Peterson WM;Yang H;Flannery JG
通讯作者：
Flannery JG