Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation.
Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation.
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DOI：
10.1002/anie.201302564
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发表时间：
2013-07-22
影响因子：
16.6
通讯作者：
Achilefu, Samuel
中科院分区：
文献类型：
--
作者：
Kotagiri, Nalinikanth;Niedzwiedzki, Dariusz M.;Ohara, Kohtaro;Achilefu, Samuel
光学成像技术已经从基本的临床前技术发展成为人类疾病诊断和治疗的临床技术平台。基于光成像和治疗技术的临床翻译的主要瓶颈是光在深部组织中的有限穿透性。这一缺陷引起了广泛的关注和对切伦科夫辐射的新兴趣，特别是在分子成像领域，作为一种与组织深度无关的自发光源切伦科夫辐射（CR）是一种光物理现象，当正电子和电子等带电粒子在折射率为>的介质中以比光更快的速度传播时，在250 - 600nm范围内发射连续波（CW）光通常，在各种临床干预中使用的高能放射性核素或外部束辐射的“副产物”会产生可观的CR。然而，由于明显的组织自身荧光、紫外和可见光的吸收和散射，切伦科夫发光成像（CLI）面临着快速信号衰减和低通量率等严峻挑战。因此，将CR与在光学窗口中发射波长在650 nm和950 nm之间的荧光团耦合，将使组织自身荧光最小化，并增强对深层组织光的检测。
Optical imaging techniques have evolved from basic preclinical to enabling clinical technology platform for the diagnosis and treatment of human diseases. A major bottleneck for the clinical translation of light based imaging and therapeutic techniques is the limited penetrability of light in deep tissue. This drawback has led to widespread attention and renewed interest in Cerenkov emission, especially in the area of molecular imaging, as a tissue depth-independent spontaneous light source.[1] Cerenkov radiation (CR) is a photophysical phenomenon where continuous wave (CW) light in the 250–600 nm range is emitted by charged particles such as positrons and electrons when travelling faster than light in a dielectric medium with refractive index> 1.[2] Generally, appreciable CR is produced as a ‘byproduct’of highly energetic radionuclide or external beam radiation that are used in various clinical interventions. However, due to significant tissue autofluorescence, absorption and scattering of UV and visible light, Cerenkov luminescence imaging (CLI) faces steep challenges such as rapid signal attenuation and low fluence rates. Thus, coupling CR with fluorophores that emit in the optical window at wavelengths between 650 nm and 950 nm will minimize tissue autofluorescence and enhance detection of light from deep tissue.
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