Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach.
Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach.
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DOI：
10.1371/journal.pone.0037623
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tian J
中科院分区：
文献类型：
--
作者：
Hu Z;Ma X;Qu X;Yang W;Liang J;Wang J;Tian J
切伦科夫发光断层成像(CLT)提供了放射性药物在小动物体内的三维生物分布，这对生物医学成像是至关重要的。然而，现有的单光谱和多光谱方法在重建放射性核素示踪剂的分布方面并不是非常有效和有效的。本文提出了一种基于Cerenkov辐射光谱特性的半定量源重建方法--混合谱CLT，该方法能够有效地重建放射性核素示踪剂，同时获得较好的重建结果，并减少采集和图像重建时间。我们建立了植入400µCi-Na131I放射源的植入小鼠模型和尾静脉注射400µCi放射性药物碘-131(I-131)的生理模型，以验证混合光谱CLT的性能，并将重建结果、采集和图像重建时间与单光谱和多光谱CLT进行了比较。此外，我们对甲状腺的I-131摄取进行了3D非侵入性监测，并使用混合光谱CLT对体内的I-131摄取进行了量化。结果表明，基于混合光谱CLT的重建在定位和定量上比单光谱CLT更准确，在活体实验中比多光谱CLT更有效。此外，纵向观测的3D可视化显示，甲状腺中I-131摄取的重建能量随着采集时间的增加而增加，并且重建能量与I-131()的伽马射线计数之间存在很强的相关性。体外生物分布实验进一步证实了混合光谱CLT在甲状腺中的摄取。结果表明，混合光谱CLT可用于甲状腺显像，以评价其功能并监测其对甲状腺癌的治疗。
Cerenkov luminescence tomography (CLT) provides the three-dimensional (3D) radiopharmaceutical biodistribution in small living animals, which is vital to biomedical imaging. However, existing single-spectral and multispectral methods are not very efficient and effective at reconstructing the distribution of the radionuclide tracer. In this paper, we present a semi-quantitative Cerenkov radiation spectral characteristic-based source reconstruction method named the hybrid spectral CLT, to efficiently reconstruct the radionuclide tracer with both encouraging reconstruction results and less acquisition and image reconstruction time. We constructed the implantation mouse model implanted with a 400 µCi Na131I radioactive source and the physiological mouse model received an intravenous tail injection of 400 µCi radiopharmaceutical Iodine-131 (I-131) to validate the performance of the hybrid spectral CLT and compared the reconstruction results, acquisition, and image reconstruction time with that of single-spectral and multispectral CLT. Furthermore, we performed 3D noninvasive monitoring of I-131 uptake in the thyroid and quantified I-131 uptake in vivo using hybrid spectral CLT. Results showed that the reconstruction based on the hybrid spectral CLT was more accurate in localization and quantification than using single-spectral CLT, and was more efficient in the in vivo experiment compared with multispectral CLT. Additionally, 3D visualization of longitudinal observations suggested that the reconstructed energy of I-131 uptake in the thyroid increased with acquisition time and there was a robust correlation between the reconstructed energy versus the gamma ray counts of I-131 (). The ex vivo biodistribution experiment further confirmed the I-131 uptake in the thyroid for hybrid spectral CLT. Results indicated that hybrid spectral CLT could be potentially used for thyroid imaging to evaluate its function and monitor its treatment for thyroid cancer.
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影响因子：
3.8
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通讯作者：
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