The global dissemination of hospital clones of Enterococcus faecium.
The global dissemination of hospital clones of Enterococcus faecium.
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DOI：
10.1186/s13073-021-00868-0
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发表时间：
2021-03-30
期刊：
影响因子：
12.3
通讯作者：
Enterococcal Group
中科院分区：
文献类型：
--
作者：
van Hal SJ;Willems RJL;Gouliouris T;Ballard SA;Coque TM;Hammerum AM;Hegstad K;Westh HT;Howden BP;Malhotra-Kumar S;Werner G;Yanagihara K;Earl AM;Raven KE;Corander J;Bowden R;Enterococcal Group
医院适应的 A1 群屎肠球菌仍然是耐药医院相关感染中值得高度关注的微生物。这种病原体如何进化和传播仍然知之甚少。收集了来自医院相关 A1 组屎肠球菌的大量具有全球代表性的短读长基因组数据 (n = 973)。我们使用一种新颖的分析方法，从辅助基因组的动态和保守基因之间的同源重组方面分析了全球多样性。基因组进化的两种主要模式继续塑造屎肠球菌：通过包括质粒在内的可移动遗传元件获得和丢失基因，包括抗菌素耐药性基因，以及核心基因组的同源重组。这些事件导致新的克隆在局部出现，随后通过重组削弱克隆信号，并在某些可识别的情况下产生新的克隆簇。这些模式导致了新的、新兴的谱系能够在相对较短的时间内在全球传播。屎肠球菌不断呈现新的基因组合以供潜在选择的能力表明，控制这种病原体仍将具有挑战性，但建立理解基因组进化的框架可能有助于追踪新出现的谱系所带来的威胁。在线版本包含可在 10.1186/s13073-021-00868-0 获取的补充材料。
The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood. A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes. Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes. The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages. The online version contains supplementary material available at 10.1186/s13073-021-00868-0.
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