Crosstalk between ILC2s and Th2 cells varies among mouse models.
Crosstalk between ILC2s and Th2 cells varies among mouse models.
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DOI：
10.1016/j.celrep.2023.112073
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发表时间：
2023-02-28
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still controversial. By generating and utilizing mouse strains that are deficient in either ILC2s or Th2 cells, we report that interleukin (IL)-33-mediated ILC2 activation promotes the Th2 cell response to papain; however, the Th2 cell response to ovalbumin (OVA)/alum immunization is thymic stromal lymphopoietin (TSLP) dependent but independent of ILC2s. During helminth infection, ILC2s and Th2 cells collaborate at different phases of the immune responses. Th2 cells, mainly through IL-4 production, induce the expression of IL-25, IL-33, and TSLP, among which IL-25 and IL-33 redundantly promote ILC2 expansion. Thus, while Th2 cell differentiation can occur independently of ILC2s, activation of ILC2s may promote Th2 responses, and Th2 cells can expand ILC2s by inducing type 2 alarmins. ILC2s and Th2 cells are involved in a variety of type 2 immune responses. Gurram et al. report that the crosstalk between ILC2s and Th2 cells varies among mouse models and is mediated by type 2 alarmins and IL-4.
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影响因子：
4.4
作者：
Claudio, Estefania;Sonder, Soren Ulrik;Saret, Sun;Carvalho, Gabrielle;Ramalingam, Thirumalai R.;Wynn, Thomas A.;Chariot, Alain;Garcia-Perganeda, Antonio;Leonardi, Antonio;Paun, Andrea;Chen, Amy;Ren, Nina Y.;Wang, Hongshan;Siebenlist, Ulrich
通讯作者：
Siebenlist, Ulrich
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
DOI：
10.1084/jem.20170494
发表时间：
2017-07-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fang D;Zhu J
通讯作者：
Zhu J
影响因子：
32.4
作者：
Morita H;Arae K;Unno H;Miyauchi K;Toyama S;Nambu A;Oboki K;Ohno T;Motomura K;Matsuda A;Yamaguchi S;Narushima S;Kajiwara N;Iikura M;Suto H;McKenzie AN;Takahashi T;Karasuyama H;Okumura K;Azuma M;Moro K;Akdis CA;Galli SJ;Koyasu S;Kubo M;Sudo K;Saito H;Matsumoto K;Nakae S
通讯作者：
Nakae S
DOI：
10.1084/jem.20171127
发表时间：
2018-05-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fang D;Cui K;Hu G;Gurram RK;Zhong C;Oler AJ;Yagi R;Zhao M;Sharma S;Liu P;Sun B;Zhao K;Zhu J
通讯作者：
Zhu J