Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms.
Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms.
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DOI：
10.1111/bdi.12054
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发表时间：
2013-05
影响因子：
5.4
通讯作者：
Birmaher B
中科院分区：
文献类型：
--
作者：
Hafeman D;Axelson D;Demeter C;Findling RL;Fristad MA;Kowatch RA;Youngstrom EA;Horwitz SM;Arnold LE;Frazier TW;Ryan N;Gill MK;Hauser-Harrington JC;Depew J;Rowles BM;Birmaher B
对于有导致损害的发作性情绪但不符合DSM-IV双相I（BD-I）或双相II（BD-II）障碍标准的儿童，其诊断分类存在争议。本研究旨在描述这些符合双相情感障碍标准（BD-NOS）的儿童与完全综合征BD的儿童相比，与没有双相情感障碍谱诊断（无BSD）的儿童相似的程度。从9家门诊招募了6-12岁的儿童，优先选择在10项躁狂症状筛查中得分较高的儿童。与儿童及其主要照顾者的访谈评估了广泛的临床变量以及家族史。共707名儿童（9.4 ± 1.9岁）在基线时接受了评估，并被诊断为BD-I（n = 71），BD-II（n = 3），BD-NOS（包括循环性心境; n = 88）或无BSD（n = 545）。与BD-I组相比，BD-NOS组的既往功能损害较轻。然而，目前的症状严重程度和功能障碍没有BD-NOS和BD-I之间的差异，即使两组的症状和损害显着比无BSD组。BD-NOS组和BD-I组的父母精神病史相似，并且两者都比无BSD组更有可能有躁狂病史的父母。率兴高采烈的情绪并没有不同的BD-NOS和BD-I青年。BD-NOS和BD-I儿童在许多现象学指标上非常相似，但与无BSD组不同。这些发现支持了BD-NOS与BD-I在相同谱上的假设。
Controversy surrounds the diagnostic categorization of children with episodic moods that cause impairment, but do not meet DSM-IV criteria for bipolar I (BD-I) or bipolar II (BD-II) disorder. This study aims to characterize the degree to which these children, who meet criteria for bipolar disorder not otherwise specified (BD-NOS), are similar to those with full syndromal BD, versus those with no bipolar spectrum diagnosis (no BSD). Children ages 6–12 years old were recruited from nine outpatient clinics, preferentially selected for higher scores on a 10-item screen for manic symptoms. Interviews with the children and their primary caregivers assessed a wide array of clinical variables, as well as family history. A total of 707 children (9.4 ± 1.9 years old) were evaluated at baseline, and were diagnosed with BD-I (n = 71), BD-II (n = 3), BD-NOS (including cyclothymia; n = 88), or no BSD (n = 545). Compared to BD-I, the BD-NOS group had less severe past functional impairment. However, current symptom severity and functional impairment did not differ between BD-NOS and BD-I, even though both groups were significantly more symptomatic and impaired than the no BSD group. Parental psychiatric history was similar for BD-NOS and BD-I groups, and both were more likely than the no BSD group to have a parent with history of mania. Rates of elated mood did not differ between BD-NOS and BD-I youth. Children with BD-NOS and BD-I are quite similar, but different from the no BSD group, on many phenomenological measures. These findings support the hypothesis that BD-NOS is on the same spectrum as BD-I.
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影响因子：
5.4
作者：
Findling, RL;Youngstrom, EA;Calabrese, JR
通讯作者：
Calabrese, JR
影响因子：
5.8
作者：
Merikangas, Kathleen R.;Pato, Michael
通讯作者：
Pato, Michael
DOI：
10.1097/00004583-198403000-00011
发表时间：
1984-01-01
影响因子：
13.3
作者：
POZNANSKI, EO;GROSSMAN, JA;GIBBONS, R
通讯作者：
GIBBONS, R
DOI：
10.1176/appi.ajp.2009.08121849
发表时间：
2009-09
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Stringaris A;Cohen P;Pine DS;Leibenluft E
通讯作者：
Leibenluft E
DOI：
10.1016/j.jaac.2010.05.017
发表时间：
2010-10
影响因子：
13.3
作者：
Merikangas KR;He JP;Burstein M;Swanson SA;Avenevoli S;Cui L;Benjet C;Georgiades K;Swendsen J
通讯作者：
Swendsen J