Current progress in neuroimaging research for the treatment of major depression with electroconvulsive therapy.
Current progress in neuroimaging research for the treatment of major depression with electroconvulsive therapy.
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电休克治疗重度抑郁症的神经影像学研究进展
DOI：
10.5498/wjp.v12.i1.128
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发表时间：
2022-01-19
影响因子：
3.1
通讯作者：
Qiu HT
中科院分区：
文献类型：
--
作者：
Li XK;Qiu HT
电休克疗法（ECT）是利用一定量的电流通过患者头部，引起全身抽搐，以缓解疾病症状，达到治疗目的。 ECT可有效改善重度抑郁症患者的临床症状，但其治疗机制尚不清楚。随着神经影像技术的快速发展，有必要从脑结构、脑功能和脑代谢等方面探讨重度抑郁症的神经生物学机制，并发现ECT可以在一定程度上改善患者的脑功能、代谢甚至脑结构。目前，越来越多的神经影像学研究采用功能磁共振成像（MRI）、正电子发射断层扫描、磁共振波谱、结构磁共振成像和扩散张量成像等各种神经影像技术来揭示ECT的神经效应。本文综述了ECT治疗重度抑郁症的神经影像学研究的最新进展。结果提示，ECT的神经生物学机制可能是调节特定脑区的功能活动和连接性或神经结构可塑性至正常水平，以达到治疗效果。
Electroconvulsive therapy (ECT) uses a certain amount of electric current to pass through the head of the patient, causing convulsions throughout the body, to relieve the symptoms of the disease and achieve the purpose of treatment. ECT can effectively improve the clinical symptoms of patients with major depression, but its therapeutic mechanism is still unclear. With the rapid development of neuroimaging technology, it is necessary to explore the neurobiological mechanism of major depression from the aspects of brain structure, brain function and brain metabolism, and to find that ECT can improve the brain function, metabolism and even brain structure of patients to a certain extent. Currently, an increasing number of neuroimaging studies adopt various neuroimaging techniques including functional magnetic resonance imaging (MRI), positron emission tomography, magnetic resonance spectroscopy, structural MRI, and diffusion tensor imaging to reveal the neural effects of ECT. This article reviews the recent progress in neuroimaging research on ECT for major depression. The results suggest that the neurobiological mechanism of ECT may be to modulate the functional activity and connectivity or neural structural plasticity in specific brain regions to the normal level, to achieve the therapeutic effect.
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