Profiles of psychiatric symptoms among amphetamine type stimulant and ketamine using inpatients in Wuhan, China.
Profiles of psychiatric symptoms among amphetamine type stimulant and ketamine using inpatients in Wuhan, China.
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DOI：
10.1016/j.jpsychires.2014.02.010
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发表时间：
2014-06
影响因子：
4.8
通讯作者：
Chawarski, Marek C.
中科院分区：
文献类型：
--
作者：
Zhang, Yao;Xu, Zaifeng;Zhang, Sheng;Desrosiers, Alethea;Schottenfeld, Richard S.;Chawarski, Marek C.
安非他明类兴奋剂（ATS）和氯胺酮已成为中国的主要毒品问题，长期大量接触这些物质经常与精神症状同时发生。本研究比较了 2010 年至 2011 年间入住中国武汉精神科病房的仅使用苯丙胺类兴奋剂、苯丙胺类兴奋剂和氯胺酮使用或仅使用氯胺酮的患者的精神症状。从他们的临床记录中收集了 375 名研究参与者的入院期间的数据，包括他们的社会人口统计数据、简明精神病评定量表 (BPRS) 分数和尿液毒理学筛查。与仅使用 ATS 和 ATS+氯胺酮组相比，仅使用氯胺酮组的 BPRS 总分显着较低，并且思维障碍、活动和敌意-怀疑 BPRS 分量表的得分也显着较低（所有比较 p<0.001）。仅服用氯胺酮组在焦虑抑郁和厌食症分量表上的得分也显着更高。与仅使用氯胺酮组和 ATS+氯胺酮组相比，仅使用 ATS 组在思维障碍、活动和敌意-怀疑分量表上的得分显着较高，而在焦虑-抑郁和厌食症分量表上得分显着较低（所有比较 p<0.001）。 K 均值聚类方法根据 BPRS 子量表概况的相似性识别出三个不同的患者聚类，并且所识别的聚类在报告不同主要滥用药物的参与者比例方面存在显着差异。研究结果表明，氯胺酮和苯丙胺类兴奋剂使用者在入院治疗时表现出不同的精神症状。
Amphetamine type stimulants (ATS) and ketamine have emerged as major drug problems in China, and chronic extensive exposure to these substances frequently co-occurs with psychiatric symptoms. This study compares the psychiatric symptoms of patients reporting ATS use only, ATS and ketamine use, or ketamine use only who were admitted to an inpatient psychiatry ward in Wuhan, China between 2010 and 2011. Data on 375 study participants collected during their ward admission and extracted from their clinical records included their socio-demographics, scores on the Brief Psychiatric Rating Scale (BPRS), and urine toxicology screens. The ketamine-only group had significantly lower total BPRS scores and significantly lower scores on Thinking Disorder, Activity, and Hostility-Suspicion BPRS subscales than the ATS-only and ATS+ketamine groups (p<0.001 for all comparisons). The ketamine-only group also had significantly higher scores on the subscales of Anxiety-Depression and Anergia. The ATS-only group had significantly higher scores on subscales of Thinking Disorder, Activity, and Hostility-Suspicion and significantly lower scores on Anxiety-Depression and Anergia subscales than the ketamine-only and ATS+ketamine groups (p<0.001 for all comparisons). A K-means cluster method identified three distinct clusters of patients based on the similarities of their BPRS subscale profiles, and the identified clusters differed markedly on the proportions of participants reporting different primary drugs of abuse. The study findings suggest that ketamine and ATS users present with different profiles of psychiatric symptoms at admission to inpatient treatment.
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影响因子：
6
作者：
Morgan, Celia J. A.;Muetzelfeldt, Leslie;Curran, H. Valerie
通讯作者：
Curran, H. Valerie
DOI：
10.1176/appi.neuropsych.12.4.480
发表时间：
2000-09-01
影响因子：
2.9
作者：
Kalechstein, AD;Newton, TF;Gawin, FH
通讯作者：
Gawin, FH
DOI：
10.1196/annals.1369.012
发表时间：
2006-01-01
期刊：
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE AND NEUROTOXICITY: COCAINE, GHB, AND SUBSTITUTED AMPHETAMINES
影响因子：
--
作者：
Akiyama, Kazufumi
通讯作者：
Akiyama, Kazufumi
DOI：
10.1177/0269881113482532
发表时间：
2013-06
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Heal DJ;Smith SL;Gosden J;Nutt DJ
通讯作者：
Nutt DJ
影响因子：
5.3
作者：
Conway, KP;Compton, W;Grant, BF
通讯作者：
Grant, BF