Inhibition of Host Gene Expression by KSHV: Sabotaging mRNA Stability and Nuclear Export.
Inhibition of Host Gene Expression by KSHV: Sabotaging mRNA Stability and Nuclear Export.
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DOI：
10.3389/fcimb.2021.648055
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发表时间：
2021
影响因子：
5.7
通讯作者：
Wu TT
中科院分区：
文献类型：
--
作者：
Pardamean CI;Wu TT
病毒以其改变宿主基因表达的能力而闻名。卡波西肉瘤相关疱疹病毒有两种蛋白质可以阻止宿主基因的表达。KSHV Sox由开放阅读框37(ORF37)编码，可引起广泛的细胞质mRNA降解，并阻断其核输出。另一种由开放阅读框10(ORF10)编码的KSHV蛋白，最近被发现通过直接作用于细胞mRNA输出途径来抑制宿主基因的表达。在本文中，我们对SOX和ORF10的研究进行综述，试图阐明它们的机制。我们还讨论了基于一种密切相关的啮齿病毒，小鼠伽马疱疹病毒-68(MHV-68)的发现如何补充KSHV的发现，以破译这两种蛋白在病毒发病机制中的作用。
Viruses are known for their ability to alter host gene expression. Kaposi sarcoma-associated herpesvirus has two proteins that obstruct host gene expression. KSHV SOX, encoded by the open reading frame 37 (ORF37), induces a widespread cytoplasmic mRNA degradation and a block on mRNA nuclear export. The other KSHV protein, encoded by the open reading frame 10 (ORF10), was recently identified to inhibit host gene expression through its direct function on the cellular mRNA export pathway. In this review, we summarize the studies on both SOX and ORF10 in efforts to elucidate their mechanisms. We also discuss how the findings based on a closely related rodent virus, murine gammaherpesvirus-68 (MHV-68), complement the KSHV findings to decipher the role of these two proteins in viral pathogenesis.
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影响因子：
3.7
作者：
Clyde, Karen;Glaunsinger, Britt A.
通讯作者：
Glaunsinger, Britt A.
影响因子：
16
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Davis, Zoe H.;Verschueren, Erik;Jang, Gwendolyn M.;Kleffman, Kevin;Johnson, Jeffrey R.;Park, Jimin;Von Dollen, John;Maher, M. Cyrus;Johnson, Tasha;Newton, William;Jaeger, Stefanie;Shales, Michael;Horner, Julie;Hernandez, Ryan D.;Krogan, Nevan J.;Glaunsinger, Britt A.
通讯作者：
Glaunsinger, Britt A.
影响因子：
5.4
作者：
Covarrubias, Sergio;Richner, Justin M.;Glaunsinger, Britt A.
通讯作者：
Glaunsinger, Britt A.
影响因子：
5.4
作者：
Elgadi, MM;Hayes, CE;Smiley, JR
通讯作者：
Smiley, JR
影响因子：
11.4
作者：
BIENROTH, S;KELLER, W;WAHLE, E
通讯作者：
WAHLE, E