Neural correlates of subjective CS/UCS association in appetitive conditioning
Neural correlates of subjective CS/UCS association in appetitive conditioning
复制标题
食欲调节中主观 CS/UCS 关联的神经相关性
DOI：
10.1002/hbm.23940
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发表时间：
2018
影响因子：
4.8
通讯作者：
Klucken
中科院分区：
文献类型：
--
作者：
Tapia León I;Stalder;Klucken
条件刺激（CS）/非条件刺激（UCS）关联的显性知识被认为是经典条件反射的重要因素。然而，虽然之前的研究重点关注它在恐惧条件反射中的作用，但它在食欲条件反射中却被忽视了。目前的功能磁共振研究旨在研究与食欲调节中主观 CS/UCS 关联相关的神经激活和功能连接。总共有 85 名受试者参与了食欲获取程序，其中中性刺激 (CS+) 与金钱奖励配对，而另一个中性刺激 (CS-) 从未与奖励配对。随后，通过测量与 CS- 相比，CS+ 被认为与 UCS 相关的程度来评估主观 CS/UCS 关联。在调节早期阶段的主观 CS/UCS 关联与初级视觉皮层 (V1) 以及调节后期阶段纹状体的激活之间建立了密切的关系。此外，我们观察到主观 CS/UCS 关联与 V1/腹内侧前额叶皮层 (vmPFC) 和纹状体/vmPFC 连接之间的负相关关系。结果表明，解耦 vmPFC 连接性参与一般奖励学习，以及注意过程在食欲调节早期阶段主观 CS/UCS 关联形成和晚期阶段奖励预测中的作用。
Explicit knowledge of conditioned stimulus (CS)/unconditioned stimulus (UCS) associations is proposed as important factor in classical conditioning. However, while previous studies have focused on its roles in fear conditioning, it has been neglected in the context of appetitive conditioning. The present functional magnetic resonance study aimed to investigate neural activation and functional connectivity linked to subjective CS/UCS association in appetitive conditioning. In total, 85 subjects participated in an appetitive acquisition procedure in which a neutral stimulus (CS+) was paired with a monetary reward, while another neutral stimulus (CS‐) was never paired with the reward. Directly afterwards, subjective CS/UCS association was assessed by measuring the extent to which the CS+ was thought to be associated with the UCS compared to the CS‐. Close relationships were established between subjective CS/UCS association and activations in the primary visual cortex (V1) during the early phase of conditioning and in the striatum during the late conditioning phase. In addition, we observed inverse relationships between subjective CS/UCS association and both V1/ventromedial prefrontal cortex (vmPFC) and striatal/vmPFC connectivity. The results suggest the involvement of decoupling vmPFC connectivity in reward learning in general and the roles of attentional processes in the formation of the subjective CS/UCS association during the early phase and reward prediction during the late phase of appetitive conditioning.
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影响因子：
6.6
作者：
Pankow, Anne;Katthagen, Teresa;Schlagenhauf, Florian
通讯作者：
Schlagenhauf, Florian
影响因子：
5.2
作者：
M. Gabriel;Lauren B. Burhans;Alireza Kashef
通讯作者：
Alireza Kashef
影响因子：
16.2
作者：
O'Doherty, JP;Buchanan, TW;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
3.7
作者：
Weike, Almut I.;Schupp, Harald T.;Hamm, Alfons O.
通讯作者：
Hamm, Alfons O.
DOI：
10.1093/brain/awu063
发表时间：
2014-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Richard C. Wolf;C. Philippi;Julian C. Motzkin;M. Başkaya;M. Koenigs
通讯作者：
Richard C. Wolf;C. Philippi;Julian C. Motzkin;M. Başkaya;M. Koenigs