Temporal lobe white matter asymmetry and language laterality in epilepsy patients.
Temporal lobe white matter asymmetry and language laterality in epilepsy patients.
复制标题
DOI：
10.1016/j.neuroimage.2009.10.055
复制
发表时间：
2010-02-01
期刊：
影响因子：
5.7
通讯作者：
Tandon, Nitin
中科院分区：
文献类型：
--
作者：
Ellmore, Timothy M.;Beauchamp, Michael S.;Breier, Joshua I.;Slater, Jeremy D.;Kalamangalam, Giridhar P.;O'Neill, Thomas J.;Disano, Michael A.;Tandon, Nitin
关键词：
近年来利用弥散张量成像（DTI）的研究使我们对服务于语言功能的白质组织有了更深入的了解。然而，DTI如何被用来准确预测语言组织的一个关键特征仍不清楚：它在一个大脑半球的不对称表征。在这项研究中，在Wada测试中有明确偏侧的癫痫患者（19名左偏侧和4名右偏侧受试者，没有双侧受试者），DTI对语言优势半球分类的预测价值相对于现有标准-颈动脉内Amytal （Wada）程序进行了评估。我们的具体假设是，单侧左右半球语言优势受试者的语言偏侧性可以通过大脑半球相对密度的不对称来预测，这三种白质通路终止于颞叶，涉及语言功能的不同方面：弓状（AF）、钩状（UF）和下纵束束（ILF）。根据高各向异性心房纤颤通路的不对称性计算的侧侧指数，而不是其他通路，以Wada结果为标准对大多数（23例中的19例）患者进行分类。结合房颤DTI、Broca区fMRI活动和利手性信息的逻辑回归模型能够根据Wada评分对23例患者中的22例（95.6%）进行正确分类。我们得出的结论是，单独评估AF的高度各向异性成分对确定语言侧性具有显著的预测能力，并且主导半球的这种明显不对称分布可能反映了额叶和颞叶之间的连接增强，以支持流畅的语言处理。鉴于本初步研究报告的样本量小，未来的研究应在更大的患者群体中评估这种方法，包括双半球优势患者。
Recent studies using diffusion tensor imaging (DTI) have advanced our knowledge of the organization of white matter subserving language function. It remains unclear, however, how DTI may be used to predict accurately a key feature of language organization: its asymmetric representation in one cerebral hemisphere. In this study of epilepsy patients with unambiguous lateralization on Wada testing (19 left and 4 right lateralized subjects; no bilateral subjects), the predictive value of DTI for classifying the dominant hemisphere for language was assessed relative to the existing standard - the intra-carotid Amytal (Wada) procedure. Our specific hypothesis is that language laterality in both unilateral left- and right-hemisphere language dominant subjects may be predicted by hemispheric asymmetry in the relative density of three white matter pathways terminating in the temporal lobe implicated in different aspects of language function: the arcuate (AF), uncinate (UF), and inferior longitudinal fasciculi (ILF). Laterality indices computed from asymmetry of high anisotropy AF pathways, but not the other pathways, classified the majority (19 of 23) of patients using the Wada results as the standard. A logistic regression model incorporating information from DTI of the AF, fMRI activity in Broca’s area, and handedness was able to classify 22 of 23 (95.6%) patients correctly according to their Wada score. We conclude that evaluation of highly anisotropic components of the AF alone has significant predictive power for determining language laterality, and that this markedly asymmetric distribution in the dominant hemisphere may reflect enhanced connectivity between frontal and temporal sites to support fluent language processes. Given the small sample reported in this preliminary study, future research should assess this method on a larger group of patients, including subjects with bihemispheric dominance.
登录
查看更多内容
影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
2
作者：
Chlebus, Pavel;Mikl, Michal;Rektor, Ivan
通讯作者：
Rektor, Ivan
影响因子：
5.6
作者：
Benke, Thomas;Koylu, Bulent;Willmes, Klaus
通讯作者：
Willmes, Klaus
影响因子：
5.7
作者：
Chen, B;Guo, H;Song, AW
通讯作者：
Song, AW
影响因子：
2.6
作者：
Brázdil, M;Zákopcan, J;Rektor, I
通讯作者：
Rektor, I