Roles of osteoclasts in alveolar bone remodeling.
Roles of osteoclasts in alveolar bone remodeling.
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DOI：
10.1002/dvg.23490
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发表时间：
2022-09
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影响因子：
--
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破骨细胞是造血来源的大型多核细胞，负责骨吸收。破骨细胞性骨吸收和成骨细胞性骨形成之间的平衡是维持骨内环境平衡的关键。牙槽骨，也称为牙槽突，是颌骨中支撑牙齿和支持口腔功能的部分。它在胚胎细胞起源、骨化形式、牙齿和牙周组织的存在等方面不同于其他骨骼；因此，了解牙槽骨改建的独特特征对于维持口腔内环境的稳定非常重要。破骨细胞性骨吸收过度是牙周炎等颌骨疾病的显著特征之一。因此，抑制破骨细胞形成和骨吸收过程一直是治疗干预的目标。了解破骨细胞性骨吸收的机制是有效治疗颌骨疾病的关键。在这篇综述中，我们讨论了牙槽骨重建的基本原理，特别是破骨细胞性骨吸收过程及其在牙槽骨中的独特功能。最后，我们提供了与颌骨骨疾病相关的破骨细胞靶向治疗和再生方法的前景。
Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone formation is critical to maintain bone homeostasis. The alveolar bone, also called the alveolar process, is the part of the jawbone that holds the teeth and supports oral functions. It differs from other skeletal bones in several aspects: its embryonic cellular origin, the form of ossification, and the presence of teeth and periodontal tissues; hence, understanding the unique characteristic of the alveolar bone remodeling is important to maintain oral homeostasis. Excessive osteoclastic bone resorption is one of the prominent features of bone diseases in the jaw such as periodontitis. Therefore, inhibiting osteoclast formation and bone resorptive process has been the target of therapeutic intervention. Understanding the mechanisms of osteoclastic bone resorption is critical for the effective treatment of bone diseases in the jaw. In this review, we discuss basic principles of alveolar bone remodeling with a specific focus on the osteoclastic bone resorptive process and its unique functions in the alveolar bone. Lastly, we provide perspectives on osteoclast‐targeted therapies and regenerative approaches associated with bone diseases in the jaw.
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影响因子：
4.2
作者：
Chavarri-Prado D;Brizuela-Velasco A;Álvarez-Arenal Á;Dieguez-Pereira M;Pérez-Pevida E;Viteri-Agustín I;Estrada-Martínez A
通讯作者：
Estrada-Martínez A
DOI：
10.1084/jem.190.12.1741
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Arai F;Miyamoto T;Ohneda O;Inada T;Sudo T;Brasel K;Miyata T;Anderson DM;Suda T
通讯作者：
Suda T
影响因子：
4.3
作者：
Chaichanasakul T;Kang B;Bezouglaia O;Aghaloo TL;Tetradis S
通讯作者：
Tetradis S
影响因子：
2.9
作者：
Arena C;Caponio VCA;Zhurakivska K;Lo Russo L;Lo Muzio L;Troiano G
通讯作者：
Troiano G
影响因子：
15.9
作者：
Aliprantis, Antonios O.;Ueki, Yasuyoshi;Glimcher, Laurie H.
通讯作者：
Glimcher, Laurie H.