MicroRNA profiling and head and neck cancer.
MicroRNA profiling and head and neck cancer.
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DOI：
10.1155/2009/837514
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发表时间：
2009
影响因子：
--
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Liu X;Chen Z;Yu J;Xia J;Zhou X
头颈部/口腔癌（HNOC）是一种毁灭性的疾病。尽管在诊断和治疗方面取得了进展，但死亡率在过去三十年中并没有显著改善。患者生存率的改善需要更好地了解疾病进展，以便在疾病过程中早期检测HNOC，并部署有针对性的治疗干预措施。越来越多的证据表明，microRNA在许多人类癌症中发挥重要作用。它们是包括增殖、分化、凋亡、存活、运动和形态发生在内的多种细胞过程的关键调节剂。microRNA表达模式可能成为HNOC诊断和预后的有力生物标志物。此外，microRNA治疗可能是HNOC预防和治疗的新策略。microRNA表达谱的最新进展使人们更好地理解了癌症的发病机制。在这篇综述中，我们将综述microRNA谱的最新技术进展及其在定义microRNA标记物/癌症预测，诊断，治疗和预后中的应用。将讨论在HNOC中一致鉴定的microRNA改变，例如miR-21、miR-31、miR-155的上调和miR-26 b、miR-107、miR-133 b、miR-138和miR-139的下调。
Head and neck/oral cancer (HNOC) is a devastating disease. Despite advances in diagnosis and treatment, mortality rates have not improved significantly over the past three decades. Improvement in patient survival requires a better understanding of the disease progression so that HNOC can be detected early in the disease process and targeted therapeutic interventions can be deployed. Accumulating evidence suggests that microRNAs play important roles in many human cancers. They are pivotal regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, and morphogenesis. MicroRNA expression patterns may become powerful biomarkers for diagnosis and prognosis of HNOC. In addition, microRNA therapy could be a novel strategy for HNOC prevention and therapeutics. Recent advances in microRNA expression profiling have led to a better understanding of the cancer pathogenesis. In this review, we will survey recent technological advances in microRNA profiling and their applications in defining microRNA markers/targets for cancer prediction, diagnostics, treatment, and prognostics. MicroRNA alterations that consistently identified in HNOC will be discussed, such as upregulation of miR-21, miR-31, miR-155, and downregulation of miR-26b, miR-107, miR-133b, miR-138, and miR-139.
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影响因子：
6.4
作者：
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通讯作者：
Califano, Joseph A.
DOI：
10.3324/haematol.12706
发表时间：
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期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
30.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.0404432101
发表时间：
2004-08-10
影响因子：
11.1
作者：
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通讯作者：
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