Regionally selective atrophy after traumatic axonal injury.
Regionally selective atrophy after traumatic axonal injury.
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DOI：
10.1001/archneurol.2010.149
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发表时间：
2010-11
影响因子：
--
通讯作者：
Diaz-Arrastia, Ramon
中科院分区：
文献类型：
--
作者：
Warner, Matthew A.;Youn, Teddy S.;Davis, Tommy;Chandra, Alvin;de la Plata, Carlos Marquez;Moore, Carol;Harper, Caryn;Madden, Christopher J.;Spence, Jeffrey;McColl, Roderick;Devous, Michael;King, Richard D.;Diaz-Arrastia, Ramon
确定弥漫性创伤性轴索损伤患者皮质和皮质下体积丢失的空间分布，并评估局部萎缩与功能预后的关系。前瞻性影像研究。使用基于高分辨率磁共振成像(MRI)的形态计量分析来评估整体和局部脑体积的纵向变化。住院创伤性脑损伤单元25例弥漫性创伤性轴索损伤患者和22例年龄和性别匹配的对照组。使用初始和后续MRI之间的整体和局部脑体积的变化来评估创伤后体积丢失的空间分布。格拉斯哥预后量表扩展是功能预后的主要衡量标准。患者经历了实质性的全脑萎缩，平均脑实质体积损失4.5%(95%可信区间：2.7-6.3%)。体积减少(误发率为0.05)出现在几个大脑区域，包括杏仁核、海马体、丘脑、胼胝体、壳核、楔前核、中央后回、中央旁小叶以及顶叶和额叶，而其他区域，如尾状和下颞叶皮质相对抵抗萎缩。全脑实质体积的丧失预示着长期的残疾，特定脑区的萎缩也预示着长期的残疾，包括顶叶下部皮质、眶部、甲周皮质和边缘上回。创伤性轴索损伤导致严重的创伤后萎缩，这种萎缩是区域性的，而不是弥漫性的，某些区域的容量损失可能对功能恢复有预后价值。
To determine the spatial distribution of cortical and subcortical volume loss in patients with diffuse traumatic axonal injury and to assess the relationship between regional atrophy and functional outcome. Prospective imaging study. Longitudinal changes in global and regional brain volumes were assessed using high-resolution magnetic resonance imaging (MRI)-based morphometric analysis. Inpatient traumatic brain injury unit Twenty-five patients with diffuse traumatic axonal injury and 22 age- and sex-matched controls. Changes in global and regional brain volumes between initial and follow-up MRI were used to assess the spatial distribution of post-traumatic volume loss. The Glasgow Outcome Scale – Extended was the primary measure of functional outcome. Patients underwent substantial global atrophy with mean brain parenchymal volume loss of 4.5% (95% Confidence Interval: 2.7 – 6.3%). Decreases in volume (at a false discovery rate of 0.05) were seen in several brain regions including the amygdala, hippocampus, thalamus, corpus callosum, putamen, precuneus, postcentral gyrus, paracentral lobule, and parietal and frontal cortices, while other regions such as the caudate and inferior temporal cortex were relatively resistant to atrophy. Loss of whole brain parenchymal volume was predictive of long-term disability, as was atrophy of particular brain regions including the inferior parietal cortex, pars orbitalis, pericalcarine cortex, and supramarginal gyrus. Traumatic axonal injury leads to substantial post-traumatic atrophy that is regionally selective rather than diffuse, and volume loss in certain regions may have prognostic value for functional recovery.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
2.8
作者：
Tae, Woo Suk;Kim, Sam Soo;Kim, Keun Woo
通讯作者：
Kim, Keun Woo
影响因子：
2.6
作者：
Ariza, Mar;Serra-Grabulosa, Josep M.;Sahuquillo, Juan
通讯作者：
Sahuquillo, Juan
DOI：
10.1073/pnas.0812697106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Agosta, Federica;Vossel, Keith A.;Gorno-Tempini, Maria Luisa
通讯作者：
Gorno-Tempini, Maria Luisa
影响因子：
2.2
作者：
McDonald, Carrie R.;Hagler, Donald J., Jr.;Halgren, Eric
通讯作者：
Halgren, Eric