Personal exposure levels of PAHs in the general population in northern rural area of Jiangsu Province, China
Personal exposure levels of PAHs in the general population in northern rural area of Jiangsu Province, China
复制标题
中国江苏省北部农村地区一般人群PAHs个人暴露水平
DOI：
10.1080/10934529.2014.846604
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Lei Li
中科院分区：
文献类型：
--
作者：
Wenqin Yin;Li Wang;Rui Li;Shuyuan Cao;Yuting Ye;Lei Li
多环芳烃（PAHs）是一组由有机物不完全燃烧产生的化合物。对人类的研究表明，多环芳烃暴露与癌症的发展之间存在关联。尿中单羟基多环芳烃（OH-PAHs）是一类多环芳烃代谢产物，可作为评估人体暴露于多环芳烃的生物标志物。我们收集了北方农村地区非职业人群的332份尿液标本。以2-羟基萘（2-OHN）、2-羟基芴（2-OHF）和1-羟基芘（1-OHP）作为生物标志物，评估人体多环芳烃负荷。在80%以上的尿样中检测到三种PAH代谢物。经尿肌酐校正后，尿中2-OHF > 1-OHP > 2-OHN。一般人群2-OHN、2-OHF、1-OHP的中位数分别为1.74、30.01、25.24 μmoL/moL肌酐。结果表明，江苏北方农村地区非职业人群暴露于极高水平的多环芳烃。尿浓度雄性动物中2-OHN、2-OHF、1-OHP的（中位数和几何平均值）（分别为1.90，0.37 ± 0.46; 34.90，1.53 ± 0.41; 27.84，1.52 ± 0.29 μmoL/moL肌酐）略高于女性（分别为1.56，0.32 ± 0.42; 29.60，1.48 ± 0.40; 23.13，1.49 ± 0.32 μmoL/moL肌酐）。而只有2-OHN在男女之间有显著性差异。
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds that are produced by incomplete combustion of organic matters. Studies in humans have shown associations between PAHs exposure and development of cancers. Urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) are a class of PAH metabolites used as biomarkers for estimating human exposure to PAHs. We collected 332 urinary samples from a nonoccupational population in northern rural area of Jiangsu. Levels of 2-hydroxynathalene (2-OHN), 2-hydroxyfluorene (2-OHF) and 1-hydroxypyrene (1-OHP) were measured as biomarkers to assess body PAHs burdens. Three PAH metabolites were detected in more than 80% of urinary samples. After being adjusted with urinary creatinine concentration, the urinary concentrations were determined as 2-OHF > 1-OHP > 2-OHN in terms. The medians of 2-OHN, 2-OHF, 1-OHP for the general population were 1.74, 30.01, 25.24 μmoL/moL creatinine, respectively. The results demonstrated that nonoccupational populations in northern rural area of Jiangsu were exposed to extremely high PAHs. The urinary concentration (median and geometric mean) of 2-OHN,2-OHF,1-OHP in males (1.90, 0.37 ± 0.46; 34.90, 1.53 ± 0.41; 27.84, 1.52 ± 0.29 μmoL/moL creatinine, respectively) was slightly higher than in females (1.56, 0.32 ± 0.42; 29.60, 1.48 ± 0.40; 23.13, 1.49 ± 0.32 μmoL/moL creatinine, respectively). However, only 2-OHN was different significantly between males and females.
DOI：
10.1016/j.jchromb.2009.02.067
发表时间：
2009-04-15
影响因子：
3
作者：
Onyemauwa, Frank;Rappaport, Stephen M.;Waidyanatha, Suramya
通讯作者：
Waidyanatha, Suramya
影响因子：
11.4
作者：
Shen, Huizhong;Huang, Ye;Wang, Rong;Zhu, Dan;Li, Wei;Shen, Guofeng;Wang, Bin;Zhang, Yanyan;Chen, Yuanchen;Lu, Yan;Chen, Han;Li, Tongchao;Sun, Kang;Li, Bengang;Liu, Wenxin;Liu, Junfeng;Tao, Shu
通讯作者：
Tao, Shu