The function of dendritic cells in modulating the host response.
The function of dendritic cells in modulating the host response.
复制标题
树突状细胞在调节宿主反应中的功能。
DOI：
10.1111/omi.12195
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发表时间：
2018-03
影响因子：
3.7
通讯作者：
Graves DT
中科院分区：
文献类型：
--
作者：
Song L;Dong G;Guo L;Graves DT
树突状细胞（dc）是抗原呈递细胞，其捕获、加工和呈递抗原到淋巴细胞以启动和调节适应性免疫反应。dc检测皮肤和粘膜中的细菌并迁移到局部淋巴结，在那里它们刺激抗原特异性T淋巴细胞和B淋巴细胞的活化和增殖。dc引导CD4 T细胞分化为T细胞亚群，如Th1、Th2、Th17和Treg细胞。牙周组织长期暴露于口腔细菌，刺激炎症反应，诱发牙龈炎或牙周炎。树突状细胞通过激活获得性免疫反应发挥保护和破坏作用，据报道也是促进骨吸收的破骨细胞前体的来源。fox01是叉头盒O转录因子家族的一员，在DCs的激活中起着重要作用。在小鼠模型中，通过FOXO1的谱系特异性缺失研究了dc在牙周炎症中的功能。FOXO1的缺失降低了DC的保护功能，增加了对牙周炎的易感性。Akt激酶磷酸化fox01抑制FOXO活性。因此，Akt-FOXO1轴可能在调节dc中发挥关键作用，从而对牙周病产生重大影响。
Dendritic cells (DCs) are antigen-presenting cells that capture, process and present antigens to lymphocytes to initiate and regulate the adaptive immune response. DCs detect bacteria in skin and mucosa and migrate into regional lymph nodes, where they stimulate antigen-specific T and B lymphocyte activation and proliferation. DCs direct CD4 T cells to differentiate to T cell subsets such as Th1, Th2, Th17 and Treg cells. The periodontium is chronically exposed to oral bacteria that stimulate an inflammatory response to induce gingivitis or periodontitis. DCs play both a protective and destructive role through activation of the acquired immune response and are also reported to be a source of osteoclast precursors that promote bone resorption. FOXO1, a member of the forkhead box O family of transcription factors, plays a significant role in the activation of DCs. The function of DCs in periodontal inflammation has been investigated in a mouse model by lineage specific deletion of FOXO1 in these cells. Deletion of FOXO1 reduces DC protective function and enhances susceptibility to periodontitis. The kinase Akt, phosphorylates FOXO1 to inhibit FOXO activity. Thus the Akt-FOXO1 axis may play a key role in regulating DCs to have a significant impact on periodontal disease.
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影响因子：
6.2
作者：
Alnaeeli, Mawadda;Park, Jaekweon;Teng, Yen-Tung A.
通讯作者：
Teng, Yen-Tung A.
影响因子：
20.1
作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
14.2
作者：
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通讯作者：
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