MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.
MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.
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DOI：
10.1002/advs.202003761
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Lacour SP
中科院分区：
文献类型：
--
作者：
Fallegger F;Schiavone G;Pirondini E;Wagner FB;Vachicouras N;Serex L;Zegarek G;May A;Constanthin P;Palma M;Khoshnevis M;Van Roost D;Yvert B;Courtine G;Schaller K;Bloch J;Lacour SP
术中皮质电图（ECoG）在手术过程中从大脑皮层表面捕获神经信息，如顽固性癫痫和肿瘤的切除。目前的临床ECoG网格是均匀间隔的，毫米大小的电极嵌入硅橡胶。它们的机械刚性和固定电极空间分辨率是外科团队报告的常见缺点。在这里，利用软神经技术的进步来制造舒适的硬膜下、薄膜ECoG网格，并评估它们对转化研究的适用性。软网格与0.2至10毫米的电极间距和直径嵌入在150微米硅酮膜。软网格与外科手术操作兼容，可以折叠以安全地连接隐藏的大脑表面，如人类尸体模型中的Sylvian褶皱。研究发现，在标准的3T临床磁共振成像扫描仪中，薄膜导体栅格不会产生妨碍诊断的成像伪影（< 1mm），也不会产生不利的局部加热。接下来，验证了软网格记录迷你猪硬脑膜下神经活动的能力。综上所述，这些结果表明，未来有可能替代当前的硬电极，并可能使软ECoG网格在转化研究和最终临床环境中得到采用。目前的临床皮质电图（ECoGs）网格由坚硬的材料制成，仅在癫痫或肿瘤手术期间提供稀疏的大脑采样。在这里，硅胶膜制成的ECoG网格可以很容易地植入尸体标本的隐藏解剖位置，并且与3T磁共振成像成像兼容。在小型猪体内模型中，符合的ECoG网格显示出高分辨率的大脑记录。
Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter‐sized electrodes embedded in silicone rubber. Their mechanical rigidity and fixed electrode spatial resolution are common shortcomings reported by the surgical teams. Here, advances in soft neurotechnology are leveraged to manufacture conformable subdural, thin‐film ECoG grids, and evaluate their suitability for translational research. Soft grids with 0.2 to 10 mm electrode pitch and diameter are embedded in 150 µm silicone membranes. The soft grids are compatible with surgical handling and can be folded to safely interface hidden cerebral surface such as the Sylvian fold in human cadaveric models. It is found that the thin‐film conductor grids do not generate diagnostic‐impeding imaging artefacts (<1 mm) nor adverse local heating within a standard 3T clinical magnetic resonance imaging scanner. Next, the ability of the soft grids to record subdural neural activity in minipigs acutely and two weeks postimplantation is validated. Taken together, these results suggest a promising future alternative to current stiff electrodes and may enable the future adoption of soft ECoG grids in translational research and ultimately in clinical settings. Current clinical electrocorticography (ECoGs) grids are made from stiff materials and only offer sparse brain sampling during epilepsy or tumor surgeries. Here conformable ECoG grids made from silicone membranes permit easy implantation in hidden anatomical locations in cadaveric specimen and imaging compatibility with 3T magnetic resonance imaging. In vivo in a minipig model the conformable ECoG grids show high‐resolution brain recordings.
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影响因子：
41.2
作者：
通讯作者：
--
影响因子：
3.5
作者：
Kaiju T;Doi K;Yokota M;Watanabe K;Inoue M;Ando H;Takahashi K;Yoshida F;Hirata M;Suzuki T
通讯作者：
Suzuki T
影响因子：
29.4
作者：
Khodagholy, Dion;Doublet, Thomas;Malliaras, George G.
通讯作者：
Malliaras, George G.
影响因子：
12.6
作者：
Ji, Bowen;Ge, Chaofan;Liu, Jingquan
通讯作者：
Liu, Jingquan
DOI：
10.1016/j.clinph.2010.04.037
发表时间：
2010-09
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Lesser RP;Crone NE;Webber WRS
通讯作者：
Webber WRS