Intravoxel incoherent motion diffusion imaging of the liver: optimal b-value subsampling and impact on parameter precision and reproducibility.
Intravoxel incoherent motion diffusion imaging of the liver: optimal b-value subsampling and impact on parameter precision and reproducibility.
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DOI：
10.1016/j.ejrad.2014.09.003
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发表时间：
2014-12
影响因子：
3.3
通讯作者：
Taouli, Bachir
中科院分区：
文献类型：
--
作者：
Dyvorne, Hadrien;Jajamovich, Guido;Kakite, Suguru;Kuehn, Bernd;Taouli, Bachir
关键词：
为了提高体素内非相干运动(IVIM)扩散加权成像(DWI)中的扩散采样效率，通过减少扩散加权(b值)的数目来提高肝脏的扩散加权成像效率。在这项IRB批准的符合HIPAA标准的前瞻性研究中，53名受试者(男性38例，平均年龄52±13岁)接受了1.5T的静脉注射磁共振弥散加权成像，使用16个b值(0到800 S/mm~2)，14名受试者进行了重复检查以评估静脉注射参数的重复性。采用双指数扩散模型对IVIM肝脏参数(PF：灌注分数，D：真扩散，D*：假扩散)进行量化。探测了16个b值的所有可能的子集，b值的数量从4到15，并对每个子集的相应参数进行了量化。对于每个b值子集，针对所有16个b值获得的参数计算全局参数估计误差，并选择提供最小误差的子集。重复检查之间的间隔扫描估计误差也被评估，以评估IVIM技术在肝脏中的重复性。选择最优的b值分布，使得b值的数量最小，同时保持参数估计误差低于扫描间重复性误差。随着b值数量的减少，所有参数的估计误差都增加了，反映了IVIM指标的精确度降低。采用4组最佳b值(0、15、150和800 S/mm~2)，D、PF和D*的误差分别为6.5、22.8和66.1%。这些值在相应参数的重测重复性范围内，D、PF和D*的误差分别为12.0%、32.3%和193.8%。一组优化的4个b值可用于估计肝脏的IVIM参数，与用作参考的16个b值采集相比，采集时间显著缩短(高达75%)，而IVIM参数的精度和重复性不会显著降低。
To increase diffusion sampling efficiency in intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver by reducing the number of diffusion weightings (b-values). In this IRB approved HIPAA compliant prospective study, 53 subjects (M/F 38/15, mean age 52 ± 13 y) underwent IVIM DWI at 1.5 T using 16 b-values (0 to 800 s/mm2), with 14 subjects having repeat exams to assess IVIM parameter reproducibility. A biexponential diffusion model was used to quantify IVIM hepatic parameters (PF: perfusion fraction, D: true diffusion and D*: pseudo diffusion). All possible subsets of the 16 b-values were probed, with number of b values ranging from 4 to 15, and corresponding parameters were quantified for each subset. For each b-value subset, global parameter estimation error was computed against the parameters obtained with all 16 b-values and the subsets providing the lowest error were selected. Interscan estimation error was also evaluated between repeat exams to assess reproducibility of the IVIM technique in the liver. The optimal b-values distribution was selected such that the number of b-values was minimal while keeping parameter estimation error below interscan reproducibility error. As the number of b-values decreased, the estimation error increased for all parameters, reflecting decreased precision of IVIM metrics. Using an optimal set of 4 b-values (0, 15, 150 and 800 s/mm2), the errors were 6.5, 22.8 and 66.1 % for D, PF and D* respectively. These values lie within the range of test-retest reproducibility for the corresponding parameters, with errors of 12.0, 32.3 and 193.8 % for D, PF and D* respectively. A set of 4 optimized b-values can be used to estimate IVIM parameters in the liver with significantly shorter acquisition time (up to 75 %), without substantial degradation of IVIM parameter precision and reproducibility compared to the 16 b-value acquisition used as the reference.
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