Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience.
Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience.
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DOI：
10.1002/jmri.22081
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发表时间：
2010-03
影响因子：
4.4
通讯作者：
Taouli, Bachir
中科院分区：
文献类型：
--
作者：
Patel, Jignesh;Sigmund, Eric E.;Rusinek, Henry;Oei, Marcel;Babb, James S.;Taouli, Bachir
目的：报告体素内非相干运动(IVIM)弥散加权磁共振成像(DW-MRI)和动态增强磁共振成像(DCE)单独及联合应用诊断肝硬变的初步经验。30例受试者(非肝硬化组16例，肝硬化组14例)接受了IVIM DW-MRI(n=27)和DCE-MRI(n=20)的前瞻性评估。IVIM参数包括灌注分数(PF)、假扩散系数(D*)、真扩散系数(D)和表观扩散系数(ADC)。无模型DCE-MR参数包括达峰时间(TTP)、上斜率和60秒曲线下的初始面积(IAUC60)。双输入单室灌注模型得到了动脉流量(Fa)、门静脉流量(Fp)、动脉分数(ART)、平均通过时间(MTT)和分布体积(DV)。应用Logistic回归和受试者操作特征分析，对每种检查方法单独和联合使用时对肝硬变的诊断性能进行评估。使用广义估计方程模型比较IVIM和DCE-MR参数。肝硬化组PF、D*、D和ADC值显著降低(P=0.0056~0.0377)，而TTP、DV和MTT值显著升高(P=0.0006~0.0154)。IVIM-MRI参数与DCE-MRI参数之间无相关性。Az值(曲线下面积)以ADC(0.808)和TTP-DV(0.952)最高。ADC与DV、TTP联合诊断肝硬变的敏感性为84.6%，特异性为100%。DW-MRI和DCE-MRI相结合可提供对肝硬变的准确诊断。
To report our preliminary experience with the use of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI) and dynamic contrast-enhanced (DCE)-MRI alone and in combination for the diagnosis of liver cirrhosis. Thirty subjects (16 with noncirrhotic liver, 14 with cirrhosis) were prospectively assessed with IVIM DW-MRI (n = 27) and DCE-MRI (n = 20). IVIM parameters included perfusion fraction (PF), pseudodiffusion coefficient (D*), true diffusion coefficient (D), and apparent diffusion coefficient (ADC). Model-free DCE-MR parameters included time to peak (TTP), upslope, and initial area under the curve at 60 seconds (IAUC60). A dual input single compartmental perfusion model yielded arterial flow (Fa), portal venous flow (Fp), arterial fraction (ART), mean transit time (MTT), and distribution volume (DV). The diagnostic performances for diagnosis of cirrhosis were evaluated for each modality alone and in combination using logistic regression and receiver operating characteristic analyses. IVIM and DCE-MR parameters were compared using a generalized estimating equations model. PF, D*, D, and ADC values were significantly lower in cirrhosis (P = 0.0056–0.0377), whereas TTP, DV, and MTT were significantly increased in cirrhosis (P = 0.0006–0.0154). There was no correlation between IVIM- and DCE-MRI parameters. The highest Az (areas under the curves) values were observed for ADC (0.808) and TTP-DV (0.952 for each). The combination of ADC with DV and TTP provided 84.6% sensitivity and 100% specificity for diagnosis of cirrhosis. The combination of DW-MRI and DCE-MRI provides an accurate diagnosis of cirrhosis.
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影响因子：
5
作者：
Jones, RA;Easley, K;Grattan-Smith, JD
通讯作者：
Grattan-Smith, JD
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13.5
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作者：
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通讯作者：
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