Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.
Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.
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悬灸天枢（ST25）抑制慢性内脏高敏大鼠脊髓前动力蛋白1及前动力蛋白受体1表达
DOI：
10.3969/j.issn.1673-5374.2012.15.004
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发表时间：
2012-05-25
影响因子：
6.1
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhao C;Qi L;Wu L;Yi T;Wu H;Guo X;Zhou C;Liu H;Wang X
悬灸可降低慢性内脏痛觉过敏大鼠结肠组织中促动素1及其受体的表达。本研究旨在验证大鼠脊髓促运动素1及其受体是否参与悬灸在肠易激综合征大鼠模型中的镇痛作用，肠易激综合征大鼠表现为慢性内脏过敏。结果表明：灸天枢穴可显著降低慢性内脏痛觉过敏大鼠对结肠膨胀的敏感性；大鼠脊髓中促运动素1和促运动素受体1的蛋白和mRNA表达均显著降低。实验结果表明，促动素1和促动素受体1参与悬灸对慢性内脏痛觉过敏大鼠的镇痛作用。
Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia.
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影响因子：
--
作者：
Robinson DR;Gebhart GF
通讯作者：
Gebhart GF
影响因子：
24.5
作者：
Naliboff, BD;Munakata, J;Mayer, EA
通讯作者：
Mayer, EA
DOI：
10.1016/s0167-4781(02)00546-8
发表时间：
2002-12-12
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Soga, T;Matsumoto, SI;Furuichi, K
通讯作者：
Furuichi, K
影响因子：
7.3
作者：
Negri, L;Lattanzi, R;Melchiorri, P
通讯作者：
Melchiorri, P
影响因子：
1.9
作者：
Joos, Stefanie;Wildau, Nicole;Brinkhaus, Benno
通讯作者：
Brinkhaus, Benno