Playing the piano with the cortex: role of neuronal ensembles and pattern completion in perception and behavior.
Playing the piano with the cortex: role of neuronal ensembles and pattern completion in perception and behavior.
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DOI：
10.1016/j.conb.2020.03.014
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发表时间：
2020-10
影响因子：
5.7
通讯作者：
Yuste R
中科院分区：
文献类型：
--
作者：
Carrillo-Reid L;Yuste R
神经元系综，即神经元的相互作用组，长期以来一直被假定为皮层回路和神经代码单元的功能构建块。神经元群体的钙成像已经证明了在体内皮层回路中广泛存在自发和感觉诱发的集合。双光子光学技术的发展，同时记录和激活神经元与单细胞分辨率（“钢琴”实验）揭示了模式完成神经元的存在，它可以触发整个合奏，并证明合奏和行为之间的因果关系。我们回顾了最近的结果控制视觉知觉与有针对性的全息操纵皮质合奏刺激模式完成神经元。将群体活动分析为神经元集合并利用模式完成可以控制健康和疾病中的大脑状态。
Neuronal ensembles, i.e. coactive groups of neurons, have been long postulated to be functional building blocks of cortical circuits and units of the neural code. Calcium imaging of neuronal populations has demonstrated the widespread existence of spontaneous and sensory-evoked ensembles in cortical circuits in vivo. The development of two-photon optical techniques to simultaneously record and activate neurons with single cell resolution (“piano” experiments) has revealed the existence of pattern completion neurons, which can trigger an entire ensemble, and demonstrated a causal relation between ensembles and behavior. We review recent results controlling visual perception with targeted holographic manipulation of cortical ensembles by stimulating pattern completion neurons. Analyzing population activity as neuronal ensembles and exploiting pattern completion could enable control of brain states in health and disease.
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