Compromised Dynamic Cerebral Autoregulation in Patients with Epilepsy.
Compromised Dynamic Cerebral Autoregulation in Patients with Epilepsy.
复制标题
癫痫患者的动态大脑自动调节功能受损。
DOI：
10.1155/2018/6958476
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发表时间：
2018
影响因子：
--
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Lv S;Guo ZN;Jin H;Sun X;Jia M;Ma H;Lv Y;Qiu Q;Liu J;Yang Y
本研究旨在分析癫痫患者的动态脑自动调节功能(DCA)。100名癫痫患者和100名年龄和性别匹配的健康对照被纳入研究。记录双侧中动脉无创连续脑血流速度和动脉血压。采用传递函数分析方法对自调节参数(相位差和增益)进行分析。癫痫患者的总相位差显著低于健康对照组(p=0.046)。此外，发作间期慢波患者的相位差明显低于无慢波患者(p=0.012)。癫痫患者局灶性放电与多灶性放电的总时相无明显差异。同时，单侧放电患者患侧和健侧大脑半球的平均时相没有差异。尤其是发作间期慢波是影响癫痫患者相位差的独立因素(p=0.016)。我们的研究证明DCA在癫痫患者中受损，特别是在发作间期慢波患者中。DCA的损害与放电的位置和类型无关。发作间期慢波是预测癫痫患者DCA受损的独立因素。本试验已在NCT02775682注册。
The aim of this study is to analyze dynamic cerebral autoregulation (dCA) in patients with epilepsy. One hundred patients with epilepsy and 100 age- and sex-matched healthy controls were recruited. Noninvasive continuous cerebral blood flow velocity of the bilateral middle artery and arterial blood pressure were recorded. Transfer function analyses were used to analyze the autoregulatory parameters (phase difference and gain). The overall phase difference of patients with epilepsy was significantly lower than that of the healthy control group (p = 0.046). Furthermore, patients with interictal slow wave had significant lower phase difference than the slow-wave-free patients (p = 0.012). There was no difference in overall phase between focal discharges and multifocal discharges in patients with epilepsy. Simultaneously, there was no difference in mean phase between the affected and unaffected hemispheres in patients with unilateral discharges. In particular, interictal slow wave was an independent factor that influenced phase difference in patients with epilepsy (p = 0.016). Our study documented that dCA is impaired in patients with epilepsy, especially in those with interictal slow wave. The impairment of dCA occurs irrespective of the discharge location and type. Interictal slow wave is an independent factor to predict impaired dCA in patients with epilepsy. This trial is registered with NCT02775682.
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DOI：
10.1159/000457036
发表时间：
1985-01-01
期刊：
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS
影响因子：
--
作者：
CLOZEL, M;DAVAL, JL;VERT, P
通讯作者：
VERT, P
影响因子：
8.3
作者：
Diehl, B;Diehl, RR;Ringelstein, EB
通讯作者：
Ringelstein, EB
影响因子：
5.6
作者：
Harris S;Boorman L;Bruyns-Haylett M;Kennerley A;Ma H;Zhao M;Overton PG;Schwartz TH;Berwick J
通讯作者：
Berwick J
影响因子：
14.5
作者：
Csercsa, Richard;Dombovari, Balazs;Ulbert, Istvan
通讯作者：
Ulbert, Istvan
影响因子：
3.5
作者：
Reinhard, M.;Rutsch, S.;Hetzel, A.
通讯作者：
Hetzel, A.