Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder.
Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum Disorder.
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DOI：
10.1002/aur.2406
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Tanguturi Y
中科院分区：
文献类型：
--
作者：
Corbett BA;Vandekar S;Muscatello RA;Tanguturi Y
自闭症谱系障碍(ASD)的特征是社交障碍和对变化的适应能力差，因此，青春期的开始可能是一个关键的转变。这项横断面研究测量了青春期的时间，以检验性别(女性与男性)和群体(自闭症与典型发育(TD))的假设差异。参与者包括239名10至13岁的儿童(137名ASD，102名TD)。ASD组包括35名女性和102名男性；TDS组包括44名女性和58名男性。在TD和ASD组中，使用性别和年龄-性别交互作用的主效应，以及男性和女性的诊断和年龄-年龄交互作用的主效应，控制体重指数、SES和种族，用线性回归方法研究以生殖器或耻骨阶段衡量的青春期开始。在TD组，男性和女性生殖器(阴茎/乳房)阶段的主效应没有差异(t=1.33，p=0.187，rdf=92)，而在自闭症儿童中，差异有统计学意义(t=2.7，p=0.008，rdf=121)。在按性别分类的诊断中，女性自闭症患者的青春期发育较早(t=1.97，p=0.053，rdf=70)，而男性则无明显差异(t=1.329，p=0.186，rdf=143)。此外，月经分析显示，女性自闭症患者的发病时间明显早于TD患者(t=RDF2.56，p=0.018，−=21)。耻骨期检查显示TD(t=2,674，p=0.009，rdf=91)和ASD(t=3.482，p=0.001，rdf=121)存在性别差异。与ASD男性和TD女性相比，患有ASD的女性青春期发作更早。研究结果强调了加强对自闭症青春期发育的了解的必要性，因为差异可能会对心理、社会、生理和发育产生重大影响。自闭症谱系障碍(ASD)儿童在社交方面有困难，对包括青春期开始和病程在内的变化反应较差。这项研究基于生殖器青春期阶段(乳房/阴茎)和阴毛发育，测量了239名儿童(137名ASD和102名TD)在10至13岁之间的青春期时间。与ASD男性和TD女性相比，患有ASD的女性青春期发作更早。研究结果强调了加强对自闭症青春期发育的了解的必要性。
Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, the onset of puberty may be a pivotal transition. This cross-sectional study measured pubertal timing to examine hypothesized differences for sex (female vs. male) and group (ASD vs. Typical development (TD)). Participants included 239 children (137 ASD, 102 TD) between 10-to-13-years. The ASD group included 35 females and 102 males; the TDs included 44 females and 58 males. Pubertal onset measured by genital or pubic stage was investigated with linear regression using main effects of sex and age-by-sex interactions in TD and ASD groups and main effects of diagnosis and diagnosis-by-age interactions in males and females, controlling for body mass index, SES, and race. In TD, examination of main effects for genital (penis/breast) stage showed no difference for male and female children (t=1.33, p=0.187, rdf=92); however, there were significant differences in ASD (t=2.70, p=0.008, rdf=121). For diagnosis modelled separately by sex, there was significantly earlier pubertal development in females with ASD (t=1.97, p=0.053, rdf=70, but not males (t=1.329, p=0.186, rdf=143). Additionally, analysis of menses revealed females with ASD had significantly earlier onset than TD (t=−2.56, p=0.018, rdf=21). Examination of pubic stage revealed expected sex differences for TD (t=2,674, p=0.009, rdf=91) and ASD (t=3.482, p=0.001, rdf=121). Females with ASD evidence advanced pubertal onset relative to ASD males and TD females. Findings underscore the need for enhanced understanding of pubertal development in ASD, as differences may have significant psychological, social, physiological and developmental consequences. Children with autism spectrum disorder (ASD) have difficulty with social communication and respond poorly to change, which may include the onset and course of puberty. The study measured the timing of puberty in 239 children (137 ASD and 102 TD) between 10-to-13-years based on pubertal stage of genital (breast/penis) and pubic hair development. Females with ASD evidence advanced pubertal onset relative to ASD males and TD females. Findings underscore the need for an enhanced understanding of pubertal development in ASD.
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影响因子：
3.7
作者：
Bramen JE;Hranilovich JA;Dahl RE;Chen J;Rosso C;Forbes EE;Dinov ID;Worthman CM;Sowell ER
通讯作者：
Sowell ER
影响因子：
8
作者：
Biro FM;Galvez MP;Greenspan LC;Succop PA;Vangeepuram N;Pinney SM;Teitelbaum S;Windham GC;Kushi LH;Wolff MS
通讯作者：
Wolff MS
影响因子：
3.3
作者：
Conley, Colleen S.;Rudolph, Karen D.
通讯作者：
Rudolph, Karen D.
DOI：
10.1352/1944-7558-116.5.381
发表时间：
2011-09-01
影响因子：
2.1
作者：
Anderson, Deborah K.;Maye, Melissa P.;Lord, Catherine
通讯作者：
Lord, Catherine
影响因子：
2.1
作者：
Compian, Laura J.;Gowen, L. Kris;Hayward, Chris
通讯作者：
Hayward, Chris