Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function.
Resting-state functional magnetic resonance imaging in clade C HIV: within-group association with neurocognitive function.
复制标题
进化枝HIV中的静止状态功能磁共振成像：与神经认知功能的组内关联。
DOI：
10.1007/s13365-017-0581-5
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发表时间：
2017-12
影响因子：
3.2
通讯作者：
Joska JA
中科院分区：
文献类型：
--
作者：
du Plessis L;Paul RH;Hoare J;Stein DJ;Taylor PA;Meintjes EM;Joska JA
Neuroimaging abnormalities are common in chronically infected HIV-positive individuals. The majority of studies have focused on structural or functional brain outcomes in samples infected with clade B HIV. While preliminary work reveals a similar structural imaging phenotype in patients infected with clade C HIV, no study has examined functional connectivity (FC) using resting state functional magnetic resonance imaging (rs-fMRI) in clade C HIV. In particular, we were interested to explore HIV-only effects on neurocognitive function using associations with rs-fMRI. In the present study, 56 treatment-naïve, clade C HIV-infected participants (age 32.27 ± 5.53 years, education 10.02 ± 1.72 years, 46 female) underwent rs-fMRI and cognitive testing. Individual resting state networks were correlated with Global Deficit Scores (GDS) in order to explore associations between them within an HIV-positive sample. Results revealed 10 regions in 6 resting state networks where FC inversely correlated with GDS scores (worse performance). The networks affected included three independent attention networks, the default mode network (DMN), sensorimotor network, and basal ganglia. Connectivity in these regions did not correlate with plasma viral load or CD4 cell count. The design of this study is unique and has not been previously reported in clade B. The abnormalities related to neurocognitive performance reported in this study of clade C may reflect late disease stage and/or unique host/viral dynamics. Longitudinal studies will help to clarify the clinical significance of resting state alterations in clade C HIV.
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影响因子：
3.1
作者：
Groenewegen HJ
通讯作者：
Groenewegen HJ
影响因子：
9.9
作者：
Ances, BM;Roc, AC;Detre, JA
通讯作者：
Detre, JA
DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
Heaton, RK;Marcotte, TD;Grant, I
通讯作者：
Grant, I
影响因子：
3
作者：
Juengst, Shannon B.;Aizenstein, Howard J.;Becker, James T.
通讯作者：
Becker, James T.
影响因子：
3.7
作者：
Ann HW;Jun S;Shin NY;Han S;Ahn JY;Ahn MY;Jeon YD;Jung IY;Kim MH;Jeong WY;Ku NS;Kim JM;Smith DM;Choi JY
通讯作者：
Choi JY