Dietary Selection Pressures and Their Impact on the Gut Microbiome.
Dietary Selection Pressures and Their Impact on the Gut Microbiome.
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DOI：
10.1016/j.jcmgh.2021.07.009
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发表时间：
2022
影响因子：
7.2
通讯作者：
Devkota S
中科院分区：
文献类型：
--
作者：
Ecklu-Mensah G;Gilbert J;Devkota S
人体肠道微生物区系是一个异质的、动态的微生物群落，它们与宿主共存，对人类的生理和健康产生显著的影响。在整个生命周期中，饮食可以通过确定将定居、持续或灭绝的微生物来塑造肠道微生物区系成员的组成和多样性。这一点并不比肠道微生物组的早期演替更明显，当时食物类型和来源相对频繁地变化，食物偏好已经确立，这在很大程度上是由地理位置以及该环境的习俗和文化惯例决定的。随着社会变得越来越流动，以及我们消费以前从未接触过的新食物，这些饮食选择压力将贯穿一生。饮食选择压力也以总体减少或过剩的形式出现，例如随着粮食不安全(缺乏食物)以及饮食肥胖(过度消费)问题的日益严重。这些都是有充分证据的饮食选择压力形式，对肠道微生物区系有深远影响，最终可能导致或恶化疾病。然而，饮食和饮食成分也可以用来促进肠道内健康的微生物功能，这将需要考虑个人历史的量身定做的方法，并取消一刀切的营养。在这里，我们总结了目前关于影响人群间和人群内肠道微生物区系结构和功能的主要膳食选择压力的知识，并讨论了针对健康和疾病的个性化膳食解决方案的潜力和实施的挑战。
The human gut microbiota harbors a heterogeneous and dynamic community of microorganisms that coexist with the host to exert a marked influence on human physiology and health. Throughout the lifespan, diet can shape the composition and diversity of the members of the gut microbiota by determining the microorganisms that will colonize, persist, or become extinct. This is no more pronounced than during early-life succession of the gut microbiome when food type and source changes relatively often and food preferences are established, which is largely determined by geographic location and the customs and cultural practices of that environment. These dietary selection pressures continue throughout life, as society has become increasingly mobile and as we consume new foods to which we have had no previous exposure. Dietary selection pressures also come in the form of overall reduction or excess such as with the growing problems of food insecurity (lack of food) as well as of dietary obesity (overconsumption). These are well-documented forms of dietary selection pressures that have profound impact on the gut microbiota that ultimately may contribute to or worsen disease. However, diets and dietary components can also be used to promote healthy microbial functions in the gut, which will require tailored approaches taking into account an individual’s personal history and doing away with one-size-fits-all nutrition. Herein, we summarize current knowledge on major dietary selection pressures that influence gut microbiota structure and function across and within populations, and discuss both the potential of personalized dietary solutions to health and disease and the challenges of implementation.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
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影响因子：
82.9
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影响因子：
12.2
作者：
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通讯作者：
Sonnenburg, Justin L.
影响因子：
82.9
作者：
Depommier, Clara;Everard, Amandine;Cani, Patrice D.
通讯作者：
Cani, Patrice D.
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.