Human postprandial responses to food and potential for precision nutrition.

Human postprandial responses to food and potential for precision nutrition.
复制标题

DOI:
10.1038/s41591-020-0934-0
复制
发表时间:
2020-06
期刊:
影响因子:
82.9
通讯作者:
Spector TD
Spector TD
中科院分区:
医学1区
文献类型:
--
作者:
Berry SE;Valdes AM;Drew DA;Asnicar F;Mazidi M;Wolf J;Capdevila J;Hadjigeorgiou G;Davies R;Al Khatib H;Bonnett C;Ganesh S;Bakker E;Hart D;Mangino M;Merino J;Linenberg I;Wyatt P;Ordovas JM;Gardner CD;Delahanty LM;Chan AT;Segata N;Franks PW;Spector TD

文献摘要

参考文献

被引文献

相似文献

对食物的代谢反应影响心脏代谢疾病的风险,但缺乏大规模的高分辨率研究。我们在英国招募了n = 1,002名双胞胎和无关的健康成年人参加PREDICT 1研究,并在诊所和家中评估了餐后代谢反应。我们观察到相同膳食的餐后血甘油三酯(103%)、葡萄糖(68%)和胰岛素(59%)反应存在较大的个体间变异性(群体变异系数[SD/均值]%)。个体特异性因素,如肠道微生物组,对餐后脂血症的影响(7.1%的方差)大于膳食宏量营养素(3.6%),但对餐后高脂血症的影响(分别为6.0%和15.4%);遗传变异对预测的影响不大(葡萄糖9.5%,甘油三酯0.8%,C肽0.2%)。在美国队列(n = 100)中对结果进行了独立验证。我们开发了一个机器学习模型,可以预测甘油三酯(r = 0.47)和血糖(r = 0.77)对食物摄入的反应。这些发现可能对制定个性化饮食策略提供信息。ClinicalTrials.gov注册号:NCT 03479866。
Metabolic responses to food influence cardiometabolic disease risk, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the UK into the PREDICT1 study and assessed postprandial metabolic responses in a clinic setting and at home. We observed large inter-individual variability (population coefficient of variation [SD/mean]%) in postprandial blood triglyceride (103%), glucose (68%), and insulin (59%) responses to identical meals. Person-specific factors, such as the gut microbiome, had a greater influence (7.1% of variance) than meal macronutrients (3.6%) for postprandial lipemia, but not for postprandial glycemia (6.0% and 15.4% respectively); genetic variants had a modest impact on predictions (9.5% for glucose, 0.8% for triglyceride, 0.2% for c-peptide). Findings were independently validated in a US cohort (n = 100). We developed a machine learning model that predicted both triglyceride (r = 0.47) and glycemic (r = 0.77) responses to food intake. These findings may be informative for developing personalized diet strategies. ClinicalTrials.gov registration: NCT03479866.
DOI: 10.1038/nmeth.3869
发表时间: 2016-07
期刊: Nature methods
影响因子: 48
作者:
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者: Holmes SP
DOI: 10.1111/j.1467-789x.2012.01011.x
发表时间: 2012-10
期刊: Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子: --
作者:
Blaak EE;Antoine JM;Benton D;Björck I;Bozzetto L;Brouns F;Diamant M;Dye L;Hulshof T;Holst JJ;Lamport DJ;Laville M;Lawton CL;Meheust A;Nilson A;Normand S;Rivellese AA;Theis S;Torekov SS;Vinoy S
通讯作者: Vinoy S
DOI: 10.1093/jn/nxy291
发表时间: 2019-03-01
影响因子: 4.2
作者:
Hansson, Patrik;Holven, Kirsten B.;Ulven, Stine M.
通讯作者: Ulven, Stine M.
DOI: 10.1016/s0140-6736(09)61457-4
发表时间: 2009-11-14
期刊: LANCET
影响因子: 168.9
作者:
Bray, G. A.;Chatellier, A.;Duncan, C.;Greenway, F. L.;Levy, E.;Ryan, D. H.;Polonsky, K. S.;Tobian, J.;Ehrmann, D.;Matulik, M. J.;Clark, B.;Czech, K.;DeSandre, C.;Hilbrich, R.;McNabb, W.;Semenske, A. R.;Goldstein, B. J.;Smith, K. A.;Wildman, W.;Pepe, C.;Goldberg, R. B.;Calles, J.;Ojito, J.;Castillo-Florez, S.;Florez, H. J.;Giannella, A.;Lara, O.;Veciana, B.;Haffner, S. M.;Montez, M. G.;Lorenzo, C.;Martinez, A.;Hamman, R. F.;Testaverde, L.;Bouffard, A.;Dabelea, D.;Jenkins, T.;Lenz, D.;Perreault, L.;Price, D. W.;Steinke, S. C.;Horton, E. S.;Poirier, C. S.;Swift, K.;Caballero, E.;Jackson, S. D.;Lambert, L.;Lawton, K. E.;Ledbury, S.;Kahn, S. E.;Montgomery, B. K.;Fujimoto, W.;Knopp, R. H.;Lipkin, E. W.;Marr, M.;Murillo, A.;Trence, D.;Kitabchi, A. E.;Murphy, M. E.;Applegate, W. B.;Bryer-Ash, M.;Dagogo-Jack, S.;Frieson, S. L.;Lambeth, H.;Lichtermann, L. C.;Otkaei, H.;Rutledge, L. M. K.;Sherman, A. R.;Smith, C. M.;Soberman, J. E.;Williams-Cleaves, B.;Metzger, B. E.;Molitch, M. E.;Johnson, M. K.;Giles, M. M.;Larsen, D.;Niznik, C.;Pen, S. C.;Schinleber, P. A.;Nathan, D. M.;McKitrick, C.;Turgeon, H.;Abbott, K.;Altshuler, D.;Anderson, E.;Bissett, L.;Cagliero, E.;D'Anna, K.;Delahanty, L.;Florez, J. C.;Goldman, V.;Poulos, A.;Tseng, B.;Barrett-Connor, E.;Carrion-Petersen, M. L.;Horne, J.;Leos, D.;Mudaliar, S.;Smith, J.;Vejvoda, K.;Pi-Sunyer, F. X.;Lee, J. E.;Foo, S. T.;Hagamen, S.;Marrero, D. G.;Kelly, S. M.;Ackermann, R. T.;Fineberg, E. S.;Hadden, A.;Jackson, M. A.;Kirkman, M. S.;Mather, K. J.;Roach, P. J.;Wheeler, M. L.;Ratner, R. E.;Aroda, V.;Shapiro, S.;Bavido-Arrage, C.;Gibbs, P.;Uwaifo, Gl;Wiggins, R.;Saad, M. F.;Watson, K.;Botrous, M.;Jinagouda, S.;Budget, M.;Conzues, C.;Magpuri, P.;Ngo, K.;Xapthalamous, K.;White, N. H.;Das, S.;Santiago, A.;Brown, A. L.;Wernimont, C.;Saudek, C. D.;Whittington, T.;Clark, J. M.;Greene, A.;Jiggetts, D.;Mosley, H.;Reusing, J.;Rubin, R. R.;Stephen, S.;Utsey, E.;Schade, D. S.;Adams, K. S.;Hemphill, C.;Hyde, P.;Butler, L.;Canady, J. L.;Colleran, K.;Gonzales, Y.;Hernandez-McGinnis, D. A.;Katz, P.;King, C.;Crandall, J.;Brown-Friday, J. O.;Adorno, E.;Duffy, H.;Martinez, H.;Pompi, D.;Shamoon, H.;Walker, E. A.;Wylie-Rosett, J.;Orchard, T.;Jeffries, S.;Kramer, M. K.;Smith, M.;Kriska, A.;Pettigrew, J.;Semler, L.;Venditti, E.;Weinzierl, V.;Arakaki, R. F.;Baker-Ladao, N. K.;Isonaga, M. K.;Bermudez, N. E.;Mau, M. K.;Knowler, W. C.;Cooeyate, N.;Hoskin, M. A.;Natewa, C.;Percy, C. A.;Acton, K. J.;Andre, V. L.;Begay, S.;Bucca, B. C.;Cook, S.;Doughty, M. S.;Glass, J.;Glass, M.;Hanson, R. L.;Hassenpflug, D.;Ingraham, L. E.;Kobus, K. M.;Krakoff, J.;Manus, C.;McCabe, C.;Michaels, S.;Morgan, T.;Nelson, J. A.;Roy, R. J.;Smart, M.;Tonemah, D. P.;Wilson, C.;Fowler, S.;Brenneman, T.;Abebe, S.;Bamdad, J.;Callaghan, J.;Christophi, C. A.;Edelstein, S. L.;Gao, Y.;Gooding, R.;Gottlieb, A.;Grover, N.;Hoffman, H.;Jablonski, K.;Katz, R.;Kolinjivadi, P.;Lachin, J. M.;Ma, Y.;Reamer, S.;Sapozhnikova, A.;Sherif, H.;Temprosa, M.;Venditti, E. M.;Kriska, A. M.;Semler, L.;Weinzierl, V.;Marcovina, S.;Strylewicz, G.;Albers, J.;Prineas, R. J.;Alexander, T.;Campbell, C.;Hall, S.;Hensley, S.;Li, Y.;Mills, M.;Soliman, E.;Zhang, Z.;Fradkin, J.;Garfield, S.;Mayer-Davis, E.;Moran, R. R.;Ganiats, T.;Sarkin, A. J.
通讯作者: Sarkin, A. J.
DOI: 10.1001/archinte.161.3.397
发表时间: 2001-02-12
影响因子: --
作者:
Borch-Johnsen, K;Neil, A;Qiao, Q
通讯作者: Qiao, Q