A new aspect of the TrkB signaling pathway in neural plasticity.
A new aspect of the TrkB signaling pathway in neural plasticity.
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DOI：
10.2174/157015909790031210
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发表时间：
2009-12
影响因子：
5.3
通讯作者：
Hayashi M
中科院分区：
文献类型：
--
作者：
Ohira K;Hayashi M
在中枢神经系统（CNS）中，分子的表达在发育过程中受到严格调控。对分子时空表达的控制不仅是一种构建功能性神经网络的机制，也是一种调节神经网络以响应来自个体外部的新信息（即通过学习和记忆）的机制。在中枢神经系统的功能分子中，研究得最好的一类是神经营养因子，它是神经生长因子（NGF）相关基因家族分子。在哺乳动物中，神经营养因子包括NGF、脑源性神经营养因子（BDNF）、神经营养因子3 （NT-3）和NT-4/5。在神经营养因子及其受体中，BDNF和原肌球蛋白相关激酶B （TrkB）在中枢神经系统中富集。在中枢神经系统中，BDNF-TrkB信号通路在整个生命过程中发挥着广泛的功能，如细胞存活、迁移、轴突和树突的生长、突触发生、突触传递和突触重塑。虽然相同的配体和受体BDNF和TrkB在这些不同的发育事件中起作用，但我们尚不清楚是什么样的机制激发了BDNF-TrkB信号通路的功能多样性。在这篇综述中，我们讨论了BDNF-TrkB信号通路作为药物治疗工具在中枢神经系统中发挥各种功能的机制。
In the central nervous system (CNS), the expression of molecules is strictly regulated during development. Control of the spatiotemporal expression of molecules is a mechanism not only to construct the functional neuronal network but also to adjust the network in response to new information from outside of the individual, i.e., through learning and memory. Among the functional molecules in the CNS, one of the best-studied groups is the neurotrophins, which are nerve growth factor (NGF)-related gene family molecules. Neurotrophins include NGF, brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and NT-4/5 in the mammal. Among neurotrophins and their receptors, BDNF and tropomyosin-related kinases B (TrkB) are enriched in the CNS. In the CNS, the BDNF-TrkB signaling pathway fulfills a wide variety of functions throughout life, such as cell survival, migration, outgrowth of axons and dendrites, synaptogenesis, synaptic transmission, and remodeling of synapses. Although the same ligand and receptor, BDNF and TrkB, act in these various developmental events, we do not yet understand what kind of mechanism provokes the functional multiplicity of the BDNF-TrkB signaling pathway. In this review, we discuss the mechanism that elicits the variety of functions performed by the BDNF-TrkB signaling pathway in the CNS as a tool of pharmacological therapy.
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影响因子：
64.8
作者：
COHENCORY, S;FRASER, SE
通讯作者：
FRASER, SE
DOI：
10.1002/neu.480251107
发表时间：
1994-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BARBACID, M
通讯作者：
BARBACID, M
影响因子：
4.8
作者：
Doussau, F;Gasman, S;Poulain, B
通讯作者：
Poulain, B
影响因子：
25
作者：
Alsina, B;Vu, T;Cohen-Cory, S
通讯作者：
Cohen-Cory, S
影响因子：
25
作者：
Bezzi, P;Gundersen, V;Volterra, A
通讯作者：
Volterra, A