Nanoparticles for imaging and treating brain cancer.
Nanoparticles for imaging and treating brain cancer.
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DOI：
10.2217/nnm.12.185
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Basilion JP
中科院分区：
文献类型：
--
作者：
Meyers JD;Doane T;Burda C;Basilion JP
脑癌肿瘤导致血管内皮细胞的选择性特性的破坏，甚至导致非常选择性的血脑屏障（统称为血脑肿瘤屏障）的破坏。纳米颗粒（NP）以前在利用其他癌症中增加的血管渗透性方面表现出很大的希望，这导致随着时间的推移，由于伴随着有效淋巴系统的丧失，这些癌症中的积累增加。因此，NP在治疗脑癌方面引起了越来越多的关注。虽然这项研究刚刚开始，但迄今为止在实验室和临床环境中已经取得了许多成功。这篇综述旨在向读者介绍用于治疗脑癌的NP的概述，并对未来可能发生的事情进行展望。对于纳米粒子，就像血脑肿瘤屏障一样，未来是广阔的。
Brain cancer tumors cause disruption of the selective properties of vascular endothelia, even causing disruptions in the very selective blood–brain barrier, which are collectively referred to as the blood–brain–tumor barrier. Nanoparticles (NPs) have previously shown great promise in taking advantage of this increased vascular permeability in other cancers, which results in increased accumulation in these cancers over time due to the accompanying loss of an effective lymph system. NPs have therefore attracted increased attention for treating brain cancer. While this research is just beginning, there have been many successes demonstrated thus far in both the laboratory and clinical setting. This review serves to present the reader with an overview of NPs for treating brain cancer and to provide an outlook on what may come in the future. For NPs, just like the blood–brain–tumor barrier, the future is wide open.
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