Pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone and 25-hydroxy vitamin D3 using tandem mass spectrometry.
Pediatric reference intervals for aldosterone, 17alpha-hydroxyprogesterone, dehydroepiandrosterone, testosterone and 25-hydroxy vitamin D3 using tandem mass spectrometry.
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DOI：
10.1016/j.clinbiochem.2009.01.015
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发表时间：
2009-06
影响因子：
2.8
通讯作者：
Soldin SJ
中科院分区：
文献类型：
--
作者：
Soldin OP;Sharma H;Husted L;Soldin SJ
确定醛固酮，17α-羟基孕酮，脱氢双足球酮，睾丸激素和25-羟基维生素D3的年龄和性别特异性儿科参考间隔。
确定新生儿的参考间隔，并使用2004年1月1日至2008年6月30日获得的门诊血液样本在儿童国家医学中心和乔治敦大学进行了0-18岁的儿童。
使用同位素稀释液色谱串联质谱法（LC/MS/MS）在儿童国家医学中心和乔治敦大学医学中心生物分析核心实验室分析血清样品。
这是一项针对从出生到18岁的儿童使用LC/MS/MS的儿童参考间隔的研究。 17α-羟基酸酯睾丸激素和季节性差异是25-羟基维生素D3的明显差异。
To determine age and sex-specific pediatric reference intervals for aldosterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D3. Reference intervals were determined for neonates and children 0–18 years of age. The study was conducted at both Children’s National Medical Center and Georgetown University using outpatient blood samples obtained between January 1, 2004 and June 30, 2008. Serum samples were analyzed using isotope dilution liquid chromatography tandem mass spectrometry (LC/MS/MS) with deuterium-labeled internal standards at Children’s National Medical Center and Georgetown University Medical Center Bioanalytical Core Laboratory. This is the first study to provide pediatric reference intervals of steroid hormones for children from birth to 18 years of age using LC/MS/MS. Reference intervals were established for aldosterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, testosterone, and 25-hydroxy vitamin D3. All the analytes exhibited at least some age dependence. Sex differences between early and late childhood and adolescence were found for 17α-hydroxyprogesterone and testosterone. Seasonal differences were apparent for 25-hydroxy vitamin D3.
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DOI：
10.1016/j.jsbmb.2008.03.005
发表时间：
2008-04-01
影响因子：
4.1
作者：
Cachofeiro, Victoria;Miana, Maria;Lahera, Vicente
通讯作者：
Lahera, Vicente
影响因子：
5
作者：
Guo, Tiedong;Taylor, Robert L.;Soldin, Steven J.
通讯作者：
Soldin, Steven J.
影响因子：
2.8
作者：
Ghoshal, AK;Soldin, SJ
通讯作者：
Soldin, SJ
影响因子：
5.8
作者：
Ankarberg-Lindgren, C;Norjavaara, E
通讯作者：
Norjavaara, E
DOI：
10.1159/000457670
发表时间：
1988-03-01
期刊：
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS
影响因子：
--
作者：
KOREN, G;FARINE, D;MACLEOD, SM
通讯作者：
MACLEOD, SM