Clinicopathological features and prognosis of gastric tube cancer after esophagectomy for esophageal cancer: a nationwide study in Japan
Clinicopathological features and prognosis of gastric tube cancer after esophagectomy for esophageal cancer: a nationwide study in Japan
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食管癌切除术后胃管癌的临床病理特征和预后：日本全国性研究
DOI：
10.1007/s10388-022-00915-8
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发表时间：
2022
期刊：
影响因子：
2.4
通讯作者：
Toh Y,
中科院分区：
文献类型：
--
作者：
Ota M;Morita M;Ikebe M;Nakashima Y;Yamamoto M;Matsubara H;Kakeji Y;Doki Y;Toh Y,
背景食管癌切除术后的幸存者有时可能会发展为胃管癌（GTC）。但其临床特征尚未阐明。我们对全国范围内的GTC进行了回顾性调查，以澄清它们。方法通过电子邮件和邮寄的方式向日本食管协会认证的116家机构发送了GTC调查问卷。 2001年至2015年间，共有62家机构诊断和治疗的608例GTC病例。结果诊断时的中位年龄为71岁，其中88.9%被诊断为I期。60%的GTC病例位于胃管肛门三分之一处，79.7%为分化型腺癌。食管切除术和 GTC 诊断之间的中位间隔为 6 年，大约 25% 的患者在 10 年后才被诊断出来。 GTC 内镜治疗和手术治疗后的 5 年总生存率 (5-OS) 分别为 75.9% 和 52.7%。无症状或通过定期随访检查诊断为 GTC 的患者与其他患者相比，显示出更好的 5-OS（分别为 69.7% vs. 41.2%，p<0.0001；71.4% vs. 41.8%，p<0.0001）。上次上消化道内镜检查（UGI）后2年内诊断的GTC病例的预后优于诊断超过2年的病例（5-OS：73.4% vs. 48.8%，p< 0.05）。结论本次全国调查首次揭示了GTC的临床病理特征。早期发现对于改善 GTC 的预后很重要，建议在食管切除术后 10 年或更长时间内每 2 年继续进行一次 UGI 内窥镜检查。
BackgroundSurvivors of esophageal cancer post-esophagectomy may sometimes develop gastric tube cancer (GTC). However, its clinical characteristics have not been elucidated. We conducted a retrospective nationwide survey of GTCs to clarify them.MethodsA questionnaire on GTCs was sent by e-mail and mail to 116 institutions certified by the Japan Esophageal Society. A total of 608 GTC cases diagnosed and treated between 2001 and 2015 were registered from 62 institutions.ResultsThe median age at diagnosis was 71 years, with 88.9% being diagnosed with stage I. Sixty percent of GTC cases were in the anal third of the gastric tube and 79.7% were differentiated adenocarcinomas. The median interval between esophagectomy and GTC diagnosis was 6 years, with approximately 25% of patients being diagnosed more than 10 years later. The 5-year overall survivals (5-OSs) after endoscopic and surgical treatments for GTC were 75.9% and 52.7%, respectively. Patients whose GTC was diagnosed without symptoms or by regular follow-up examination showed better 5-OSs compared to others (69.7% vs. 41.2%,p< 0.0001; and 71.4% vs. 41.8%,p< 0.0001, respectively). The prognosis of GTC cases diagnosed within 2 years of the preceding upper gastrointestinal endoscopy (UGI) was better than that in cases diagnosed longer than 2 years (5-OS: 73.4% vs. 48.8%,p< 0.05).ConclusionThis nationwide survey revealed the clinicopathological features of GTCs for the first time. Early detection is important in improving the prognosis of GTC, and it is recommended that UGI endoscopy be continued every 2 years for 10 or more years after esophagectomy.
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影响因子：
2.5
作者：
KUWANO, H;MORITA, M;SUGIMACHI, K
通讯作者：
SUGIMACHI, K
台湾食管癌患者的第二个原发性恶性风险：一项基于人群的研究。
影响因子：
3.7
作者：
Chen SC;Teng CJ;Hu YW;Yeh CM;Hung MH;Hu LY;Ku FC;Tzeng CH;Chiou TJ;Chen TJ;Liu CJ
通讯作者：
Liu CJ
2014年，日本食管癌的综合注册表。
DOI：
10.1007/s10388-021-00879-1
发表时间：
2022-01
期刊：
Esophagus : official journal of the Japan Esophageal Society
影响因子：
--
作者：
Watanabe M;Toh Y;Ishihara R;Kono K;Matsubara H;Murakami K;Muro K;Numasaki H;Oyama T;Ozawa S;Saeki H;Tanaka K;Tsushima T;Ueno M;Uno T;Yoshio T;Usune S;Takahashi A;Miyata H;Registration Committee for Esophageal Cancer of the Japan Esophageal Society
通讯作者：
Registration Committee for Esophageal Cancer of the Japan Esophageal Society
台湾弥漫型和肠型胃癌的独特临床病理特征。
影响因子：
2.9
作者：
M. S. Wu;K. C. Yang;C. Shun;T. Hsiao;C. C. Lin;H. ;S. Chuang;W. J. Lee;J. T. Lin
通讯作者：
J. T. Lin
DOI：
10.1007/s101200200002
发表时间：
2002-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Kondo, Ken
通讯作者：
Kondo, Ken