Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice.
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice.
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DOI：
10.1007/s10522-022-09996-5
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发表时间：
2022-12
期刊：
影响因子：
4.5
通讯作者：
Stern, Jennifer H.
中科院分区：
文献类型：
--
作者：
Peters, Emily C.;Safayan, Luke;Marx, Tyler J.;Ngu, Emily;Vasileva, Anastasiia;Zappia, India;Powell, William H.;Duca, Frank A.;Stern, Jennifer H.
长期热量限制（CR）可以延长寿命，降低疾病风险。许多先前的研究已经实施了30-40%的卡路里限制来调查这些好处。我们的研究目的是调查从4个月大开始的卡路里限制对衰老引起的代谢和身体变化的影响。从美国国家衰老研究所（NIA）获得雄性C57BL/6NCrl热量限制和自由喂养的对照小鼠，分别在10、18、26和28个月大时进行研究，以更好地了解中老年对CR的反应所发生的代谢变化。在随意喂养的对照组中测量食物摄入量，以评估这些小鼠的真实CR程度（15%）。我们发现15% CR降低了10个月和18个月大小鼠的体重和肝脏甘油三酯含量，改善了口服葡萄糖清除率，并增加了所有肢体握力。26月龄和28月龄小鼠的葡萄糖清除率相对于年轻小鼠有所提高，但CR没有进一步改善。CR降低了所有年龄组的基础胰岛素浓度，并改善了28月龄小鼠的胰岛素敏感性和旋转周期下降时间。我们的研究结果表明，即使是适度减少（15%）的热量摄入也可能改善代谢和身体健康。因此，适度的卡路里限制可能是一种饮食干预，以促进健康老龄化，提高人类坚持的可能性。
Chronic calorie restriction (CR) results in lengthened lifespan and reduced disease risk. Many previous studies have implemented 30–40% calorie restriction to investigate these benefits. The goal of our study was to investigate the effects of calorie restriction, beginning at 4 months of age, on metabolic and physical changes induced by aging. Male C57BL/6NCrl calorie restricted and ad libitum fed control mice were obtained from the National Institute on Aging (NIA) and studied at 10, 18, 26, and 28 months of age to better understand the metabolic changes that occur in response to CR in middle age and advanced age. Food intake was measured in ad libitum fed controls to assess the true degree of CR (15%) in these mice. We found that 15% CR decreased body mass and liver triglyceride content, improved oral glucose clearance, and increased all limb grip strength in 10- and 18-month-old mice. Glucose clearance in ad libitum fed 26- and 28-month-old mice is enhanced relative to younger mice but was not further improved by CR. CR decreased basal insulin concentrations in all age groups and improved insulin sensitivity and rotarod time to fall in 28-month-old mice. The results of our study demonstrate that even a modest reduction (15%) in caloric intake may improve metabolic and physical health. Thus, moderate calorie restriction may be a dietary intervention to promote healthy aging with improved likelihood for adherence in human populations.
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DOI：
10.1093/gerona/glt160
发表时间：
2014-08-01
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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影响因子：
4.3
作者：
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通讯作者：
Loria, Paola
DOI：
10.1073/pnas.0904944106
发表时间：
2009-09-08
影响因子：
11.1
作者：
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通讯作者：
Klein, Samuel