Cerebellar Contributions to Social Cognition in ASD: A Predictive Processing Framework.

Cerebellar Contributions to Social Cognition in ASD: A Predictive Processing Framework.
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小脑对ASD中社会认知的贡献:一个预测处理框架。

DOI:
10.3389/fnint.2022.810425
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发表时间:
2022
影响因子:
3.5
通讯作者:
D'Mello AM
D'Mello AM
中科院分区:
医学3区
文献类型:
--
作者:
Frosch IR;Mittal VA;D'Mello AM

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在自闭症谱系障碍(ASD)中,小脑的功能,结构和细胞结构差异一直被报道。尽管如此,小脑对ASD的作用机制,特别是在社会认知领域,还没有得到很好的理解。最近,有人提出,ASD的几个核心特征可能与创建和使用先前预期或预测以快速适应变化的刺激或情况的挑战有关,也称为自适应预测。重要的是,神经影像学,临床和动物研究发现,小脑支持运动和非运动领域的适应性预测。通过损伤或神经调节对小脑的扰动与预测技能的损害有关。在这里,我们回顾了小脑在ASD患者和非ASD患者的社会认知和适应性预测中的作用的证据。
Functional, structural, and cytoarchitectural differences in the cerebellum are consistently reported in Autism Spectrum Disorders (ASD). Despite this, the mechanisms governing cerebellar contributions to ASD, particularly within the sociocognitive domain, are not well understood. Recently, it has been suggested that several core features of ASD may be associated with challenges creating and using prior expectations or predictions to rapidly adapt to changing stimuli or situations, also known as adaptive prediction. Importantly, neuroimaging, clinical, and animal work find that the cerebellum supports adaptive prediction in both motor and non-motor domains. Perturbations to the cerebellum via injury or neuromodulation have been associated with impairments in predictive skills. Here, we review evidence for a cerebellar role in social cognition and adaptive prediction across individuals with and without ASD.
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