Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis.
Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis.
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健康和疾病中的脂质和脂蛋白：专注于靶向动脉粥样硬化。
DOI：
10.3390/biomedicines9080985
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发表时间：
2021-08-09
期刊：
影响因子：
4.7
通讯作者：
Wu MS
中科院分区：
文献类型：
--
作者：
Lee CK;Liao CW;Meng SW;Wu WK;Chiang JY;Wu MS
尽管在药物治疗、干预设备和技术方面取得了进展，但残留的心血管风险仍然对公共卫生造成很大负担。虽然大多数指南鼓励达到特定脂质和脂蛋白的目标水平以降低这些风险，但越来越多的证据表明，这些脂蛋白的分子修饰也对其动脉粥样硬化性有关键影响。低密度脂蛋白（LDL）的氧化、糖基化、过氧化、载脂蛋白C-III粘附和小致密亚型在很大程度上增强了其致动脉粥样硬化性。氧化、氨甲酰化、糖基化和分子成分失衡等翻译后修饰可降低高密度脂蛋白（HDL）逆向胆固醇运输的能力。甘油三酯（tg）、载脂蛋白C-III和脂蛋白(a)水平升高以及载脂蛋白a - i水平下降与动脉粥样硬化性心血管疾病密切相关。旨在降低tg、脂蛋白(a)和载脂蛋白C-III以及增强载脂蛋白a -1的药物疗法正在进行试验，并已报道了有希望的初步结果。在这篇综述中，我们旨在更新主要脂质和脂蛋白成分的修饰证据，包括LDL， HDL， TG，载脂蛋白和脂蛋白(a)。我们还讨论了将基础研究成果转化为药物开发潜在治疗靶点的例子。
Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce these risks, increasing evidence has shown that molecular modification of these lipoproteins also has a critical impact on their atherogenicity. Modification of low-density lipoprotein (LDL) by oxidation, glycation, peroxidation, apolipoprotein C-III adhesion, and the small dense subtype largely augment its atherogenicity. Post-translational modification by oxidation, carbamylation, glycation, and imbalance of molecular components can reduce the capacity of high-density lipoprotein (HDL) for reverse cholesterol transport. Elevated levels of triglycerides (TGs), apolipoprotein C-III and lipoprotein(a), and a decreased level of apolipoprotein A-I are closely associated with atherosclerotic cardiovascular disease. Pharmacotherapies aimed at reducing TGs, lipoprotein(a), and apolipoprotein C-III, and enhancing apolipoprotein A-1 are undergoing trials, and promising preliminary results have been reported. In this review, we aim to update the evidence on modifications of major lipid and lipoprotein components, including LDL, HDL, TG, apolipoprotein, and lipoprotein(a). We also discuss examples of translating findings from basic research to potential therapeutic targets for drug development.
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影响因子：
4.5
作者：
Amini M;Zayeri F;Salehi M
通讯作者：
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影响因子：
39.3
作者：
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Bowden DW
影响因子：
120.7
作者：
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通讯作者：
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