Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort.
Birth weight, body silhouette over the life course, and incident diabetes in 91,453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort.
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DOI：
10.2337/dc09-1304
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发表时间：
2010-02
期刊：
影响因子：
16.2
通讯作者：
Clavel-Chapelon F
中科院分区：
文献类型：
--
作者：
de Lauzon-Guillain B;Balkau B;Charles MA;Romieu I;Boutron-Ruault MC;Clavel-Chapelon F
肥胖和成人体重增加被认为是2型糖尿病最重要的危险因素之一。低出生体重也与较高的糖尿病发病率有关。我们的目的是研究从童年到成年的体型演变在多大程度上与成年后期的糖尿病事件有关。E3 N是对1925-1950年出生的法国妇女进行的一项队列研究，每两年进行一次问卷调查。在1990年的基线上，女性被要求报告她们目前的体重，身高和不同年龄的身体轮廓。2002年记录了出生体重。糖尿病病例由患者自行报告或通过药品报销记录链接获得，并进一步验证。在91，453名基线时无糖尿病的女性中，2，534名在15年的随访中患上了糖尿病。出生体重和8岁时、初潮时和青年期（20-25岁）的身体轮廓与糖尿病风险呈负相关，与随访期间的成人BMI无关（所有P趋势< 0.001）。在成年中期（35-40岁），这种关联被逆转，与更大的身体轮廓相关的风险增加。从童年到中年，身体轮廓的增加了患糖尿病的风险。低出生体重和消瘦直到成年可能会增加糖尿病的风险，独立于随访期间的成人BMI。应该特别警告那些瘦瘦的年轻妇女不要发胖。
Obesity and increases in body weight in adults are considered to be among the most important risk factors for type 2 diabetes. Low birth weight is also associated with a higher diabetes incidence. We aimed to examine to what extent the evolution of body shape, from childhood to adulthood, is related to incident diabetes in late adulthood. Etude Epidemiologique de Femmes de la Mutuelle Générale de l'Education Nationale (E3N) is a cohort study of French women born in 1925–1950 and followed by questionnaire every 2 years. At baseline, in 1990, women were asked to report their current weight, height, and body silhouette at various ages. Birth weight was recorded in 2002. Cases of diabetes were self-reported or obtained by drug reimbursement record linkage and further validated. Of the 91,453 women who were nondiabetic at baseline, 2,534 developed diabetes over the 15 years of follow-up. Birth weight and body silhouette at 8 years, at menarche, and in young adulthood (20–25 years) were inversely associated with the risk of diabetes, independently of adult BMI during follow-up (all Ptrend < 0.001). In mid-adulthood (35–40 years), the association was reversed, with an increase in risk related to a larger body silhouette. An increase in body silhouette from childhood to mid-adulthood amplified the risk of diabetes. Low birth weight and thinness until young adulthood may increase the risk of diabetes, independently of adult BMI during follow-up. Young women who were lean children should be especially warned against weight gain.
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影响因子：
7.7
作者：
Iliadou, A;Cnattingius, S;Lichtenstein, P
通讯作者：
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影响因子：
158.5
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影响因子：
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作者：
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Stampfer, MJ