Parental genetic contributions to neonatal temperament in a nonhuman primate (Macaca mulatta) model.
Parental genetic contributions to neonatal temperament in a nonhuman primate (Macaca mulatta) model.
复制标题
DOI：
10.1002/dev.22106
复制
发表时间：
2021-07
影响因子：
2.2
通讯作者：
Higley, J. Dee
中科院分区：
文献类型：
--
作者：
Wood, Elizabeth K.;Hunter, Jacob N.;Olsen, Joseph A.;Almasy, Laura;Lindell, Stephen G.;Goldman, David;Barr, Christina S.;Suomi, Stephen J.;Kay, Daniel B.;Higley, J. Dee
气质是个体的天性，人们普遍认为它有遗传基础。然而，很少有研究评估父母对气质的三个维度的贡献。恒河猴由于其与人类密切的遗传相关性和共同的气质结构，被广泛用于模拟遗传对人类发展的贡献，为研究父母遗传对气质的影响提供了一个有力的转化模型。在生命的第一个月，通过比较在符合物种规范的条件下由母亲抚养或在新生儿保育室抚养的同父异母或同母异父的兄弟姐妹的气质，对19个不同父系和50个不同母系的恒河猴幼崽的气质进行了评估。获得了气质三个维度（定向/调节、消极情感和活力/外向性）的因子得分，并使用方差分析来评估遗传效应。对于同父异母的兄弟姐妹，结果显示父亲对定向/调节、消极情感和活力/外向性因子得分有统计学上显著的贡献。对于同母异父的兄弟姐妹，结果显示对定向/调节因子得分有统计学上显著的贡献。按早期抚养条件细分时，结果显示在新生儿保育室抚养的同父异母的兄弟姐妹的定向/调节、消极情感和活力/外向性得分有父亲的贡献，而由母亲抚养的同父异母的兄弟姐妹只有活力/外向性有父亲的贡献。由母亲抚养的同母异父的兄弟姐妹只有定向/调节有母亲的贡献。这些结果表明，父母对气质的贡献因环境背景而异，母亲可能会在环境上缓冲婴儿免受父亲对其气质的影响。
Temperament is an individual’s nature and is widely believed to have a heritable foundation. Few studies, however, have evaluated paternal and maternal contributions to the triadic dimensions of temperament. Rhesus monkeys are widely utilized to model genetic contributions to human development due to their close genetic-relatedness and common temperament structure, providing a powerful translational model for investigating paternal and maternal genetic influences on temperament. The temperament of rhesus monkey infants born to 19 different sires and 50 different dams was assessed during the first month of life by comparing the temperament of paternal or maternal half-siblings reared with their mothers in species-normative conditions or reared in a neonatal nursery. Factor scores from three dimensions of temperament were obtained (Orienting/Regulation, Negative Affectivity, and Surgency/Extraversion) and ANOVAs were used to assess genetic effects. For paternal half-siblings, results showed a statistically significant paternal contribution to Orienting/Regulation, Negative Affectivity, and Surgency/Extraversion factor scores. For maternal half-siblings, results showed a statistically significant contribution to Orienting/Regulation factor scores. When parsed by early rearing condition, results showed a paternal contribution Orienting/Regulation, Negative Affectivity, and Surgency/Extraversion scores for paternal half-siblings reared in the neonatal nursery, while there was only a paternal contribution to Surgency/Extraversion for paternal half-siblings reared by their mothers. There was only a maternal contribution to Orienting/Regulation for maternal half-siblings reared by their mothers. These results show that paternal and maternal contributions to temperament vary by environmental context, and that mothers may environmentally buffer their infants from paternal contributions to their temperament.
登录
查看更多内容
DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
DOI：
10.1111/j.1532-7078.2012.00119.x
发表时间：
2013-03
期刊：
Infancy : the official journal of the International Society on Infant Studies
影响因子：
--
作者：
Gartstein MA;Bridgett DJ;Young BN;Panksepp J;Power T
通讯作者：
Power T
影响因子：
2.1
作者：
Bridgett, David J.;Gartstein, Maria A.;Lee, Lindsay
通讯作者：
Lee, Lindsay
影响因子：
2.1
作者：
Kay, Daniel B.;Marsiske, Michael;Suomi, Stephen J.;Higley, J. Dee
通讯作者：
Higley, J. Dee
DOI：
10.1176/appi.ajp.2016.15111381
发表时间：
2016-09-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Hyde LW;Waller R;Trentacosta CJ;Shaw DS;Neiderhiser JM;Ganiban JM;Reiss D;Leve LD
通讯作者：
Leve LD