Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases.
Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases.
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藻类衍生的营养素作为对抗Covid-19和人类冠状病毒疾病的补充。
DOI：
10.1016/j.nut.2020.111089
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Bux F
中科院分区：
文献类型：
--
作者：
Ratha SK;Renuka N;Rawat I;Bux F
由严重急性呼吸综合征冠状病毒2型引发全球巨大恐慌的2019年冠状病毒病(新冠肺炎)暴发，死亡率在0.5%至1%之间，而且还在不断增长。目前还没有治疗方法和/或疫苗可以帮助减轻这种病毒性疾病，但口罩的使用和社会距离可以限制传播。提高免疫力一直是抵抗病毒感染和限制死亡的一种简单方法。在这种情况下，使用营养食品似乎是一种潜在的灵丹妙药。以藻类为基础的营养食品，主要是螺旋藻，提高对病毒疾病的免疫力的能力已经被临床报道。螺旋藻类营养食品可增强机体的适应性免疫和天然免疫功能，而血管紧张素转换酶(ACE)抑制物肽、藻胆蛋白、硫酸多糖、螺旋藻多糖等生物活性物质可作为抗病毒药物。这些分子的存在表明了它在抵抗感染和新冠肺炎疾病进展方面的潜在作用。本文综述了藻类营养食品作为免疫增强剂在对抗人类冠状病毒和其他病毒性疾病方面的潜在作用。还讨论了以螺旋藻为基础的营养食品在对抗新冠肺炎方面的潜在用途、其机制和未来的发展方向。
The outbreak of the coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 that has created huge trepidation worldwide, has a mortality rate of 0.5% to 1% and is growing incessantly. There are currently no therapies and/or vaccines that may help abate this viral disease, but the use of masks and social distancing can limit the spread. Boosting immunity has been a simple way to resist viral infection and limit fatalities. In this context, the use of nutraceuticals appears to be a potential panacea. The ability of algae-based nutraceuticals, mainly Spirulina, to boost immunity against viral diseases has already been reported clinically. Spirulina-based nutraceuticals boost the adaptive and innate immunity, and bioactive compounds, such as angiotensin-converting enzyme (ACE) inhibitor peptides, phycobiliproteins, sulfated polysaccharides, and calcium-Spirulan, can serve as antiviral agents. The presence of these molecules indicates its potential role in resisting infection and COVID-19 disease progression. This review focuses on the potential role of algal nutraceuticals as immune boosters to combat the human coronavirus and other viral diseases. The potential use of Spirulina-based nutraceuticals for combating COVID-19, its mechanism, and future directions have also been discussed.
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