Emergence of a group 3 coronavirus through recombination.
Emergence of a group 3 coronavirus through recombination.
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DOI：
10.1016/j.virol.2009.11.044
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发表时间：
2010-03-01
期刊：
影响因子：
3.7
通讯作者：
Byrd LA
中科院分区：
文献类型：
--
作者：
Jackwood MW;Boynton TO;Hilt DA;McKinley ET;Kissinger JC;Paterson AH;Robertson J;Lemke C;McCall AW;Williams SM;Jackwood JW;Byrd LA
对火鸡冠状病毒（TCoV）进行了分析，TCoV是一种肠道疾病病毒，与鸡的传染性支气管炎病毒（IBV）高度相似，IBV是一种上呼吸道疾病病毒，旨在确定适应潜力以及与第3组冠状病毒出现相关的遗传变化。对家禽有致病性而对鸡无致病性的TCoV毒株不适应于引起鸡的疾病。比较基因组学揭示了两个重组位点，用可能来自另一种冠状病毒的未鉴定序列取代了IBV中的刺突基因，导致跨物种传播和致病性转变。在火鸡中出现后，TCoV通过刺突内突变的积累而分化为不同的血清型。这是第一个证明重组可以直接导致新冠状病毒和新冠状病毒疾病出现的证据，强调了限制暴露于冠状病毒储库的重要性，这些储库可以作为新出现病毒的遗传物质来源。
Analyses of turkey coronavirus (TCoV), an enteric disease virus that is highly similar to infectious bronchitis virus (IBV) an upper-respiratory tract disease virus in chickens, were conducted to determine the adaptive potential, and genetic changes associated with emergence of this group 3 coronavirus. Strains of TCoV that were pathogenic in poults and nonpathogenic in chickens did not adapt to cause disease in chickens. Comparative genomics revealed two recombination sites that replaced the spike gene in IBV with an unidentified sequence likely from another coronavirus, resulting in cross-species transmission and a pathogenicity shift. Following emergence in turkeys, TCoV diverged to different serotypes through the accumulation of mutations within spike. This is the first evidence that recombination can directly lead to the emergence of new coronaviruses and new coronaviral diseases, emphasizing the importance of limiting exposure to reservoirs of coronaviruses that can serve as a source of genetic material for emerging viruses.
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