Neural crest lineage segregation: a blueprint for periodontal regeneration.

Neural crest lineage segregation: a blueprint for periodontal regeneration.
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DOI:
10.1177/0022034509340641
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发表时间:
2009-09
影响因子:
7.6
通讯作者:
Druzinsky R
Druzinsky R
中科院分区:
医学1区
文献类型:
--
作者:
Luan X;Dangaria S;Ito Y;Walker CG;Jin T;Schmidt MK;Galang MT;Druzinsky R

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During the recent decade, the periodontal attachment apparatus has turned into one of the premier areas of the body for the development of novel tissue engineering strategies. In the present review we are using a developmental biology approach to characterize current concepts in periodontal regeneration and to discuss strategies for future applications in periodontal therapies. In order to decipher the developmental make-up of the periodontal region, we have followed the path of the migratory neural crest as it gives rise to periodontal progenitor tissues, which in turn are subjected to the influence of diverse craniofacial extracellular matrices and peptide growth factors. Based on this developmental perspective, we have conducted a systematic analysis of the factors, progenitor cells, and matrices used in current periodontal tissue engineering approaches. We propose that the developmental history of a tissue is a highly instructive design template for the discovery of novel bioengineering tools and approaches.
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