Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways.
Seaweed-Derived Polysaccharides Attenuate Heat Stress-Induced Splenic Oxidative Stress and Inflammatory Response via Regulating Nrf2 and NF-κB Signaling Pathways.
复制标题
海藻衍生的多糖通过调节NRF2和NF-κB信号传导途径来减轻热应力诱导的脾脏氧化应激和炎症反应。
作者：
随着全球变暖，热应激（HS）已成为人类和动物的一个全球性问题。利用动物模型（原鸡）评价海藻（浒苔）衍生多糖（SDP）对HS诱导的氧化应激和免疫器官（脾）的炎症反应的改善作用。在这项为期4周的试验中总共使用了144只动物，并将其随机分配至以下三组：热中性区、HS和补充1000 mg/kg SDP的HS组。SDP通过增强核因子红细胞2相关因子2（Nrf 2）信号通路，提高了应激时脾脏的抗氧化能力，降低了丙二醛（MDA）含量。此外，包含SDP通过抑制核因子-κ B（NF-κB）p65信号转导降低促炎细胞因子水平并减轻HS诱导的脾炎症反应。这些结果表明，E. Prolifera可用作功能性食品和/或饲料补充剂，以减弱HS诱导的氧化应激和免疫器官的炎症反应。此外，由于海藻具有抗氧化和抗炎作用，研究结果可能有助于从海藻中开发高价值的海洋产品，供人类和动物使用。
With global warming, heat stress (HS) has become a worldwide concern in both humans and animals. The ameliorative effect of seaweed (Enteromorpha prolifera) derived polysaccharides (SDP) on HS-induced oxidative stress and the inflammatory response of an immune organ (spleen) was evaluated using an animal model (Gallus gallus domesticus). In total, 144 animals were used in this 4-week trial and randomly assigned to the following three groups: thermoneutral zone, HS, and HS group supplemented with 1000 mg/kg SDP. Dietary SDP improved the antioxidant capacity and reduced the malondialdehyde (MDA) of the spleen when exposed to HS, regulated via enhancing nuclear factor erythroid 2-related factor-2 (Nrf2) signaling. Furthermore, the inclusion of SDP reduced the levels of pro-inflammatory cytokines and alleviated HS-induced splenic inflammatory response by suppressing the nuclear factor-kappa B (NF-κB) p65 signaling. These findings suggest that the SDP from E. prolifera can be used as a functional food and/or feed supplement to attenuate HS-induced oxidative stress and inflammatory responses of the immune organs. Moreover, the results could contribute to the development of high-value marine products from seaweed for potential use in humans and animals, owing to their antioxidant and anti-inflammatory effects.
登录
查看更多内容
DOI：
10.3390/antiox10010035
发表时间：
2020-12-30
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Emami NK;Jung U;Voy B;Dridi S
通讯作者：
Dridi S
影响因子：
--
作者：
Chi, Qianru;Wang, Dongxu;Li, Shu
通讯作者：
Li, Shu
影响因子：
3.5
作者：
Banerjee, BD;Seth, V;Chakraborty, AK
通讯作者：
Chakraborty, AK
影响因子：
4.4
作者：
Guo Y;Zhao ZH;Pan ZY;An LL;Balasubramanian B;Liu WC
通讯作者：
Liu WC
影响因子：
5.6
作者：
Dong, Na;Li, Xinran;Li, Deshan
通讯作者：
Li, Deshan