Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.
Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.
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DOI：
10.1371/journal.pone.0120313
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Suda T
中科院分区：
文献类型：
--
作者：
Hozumi H;Enomoto N;Kono M;Fujisawa T;Inui N;Nakamura Y;Sumikawa H;Johkoh T;Nakashima R;Imura Y;Mimori T;Suda T
在多发性肌炎/皮肌炎（PM/DM）中，抗氨酰-tRNA合成酶（ARS）抗体与间质性肺病（ILD）密切相关，ILD是一种常见的肺部并发症。然而，抗ARS抗体的临床意义还没有很好地建立。我们的目的是评价抗ARS抗体在PM/DM-ILD患者中的临床意义。回顾性研究了48例连续PM/DM-ILD患者。用ELISA法筛选抗ARS抗体，并用RNA免疫沉淀试验证实。比较ARS阳性（ARS组）和ARS阴性（非ARS组）患者的病历、高分辨率计算机断层扫描图像和手术肺活检标本。48例患者中有23例（48%）检测到抗ARS抗体。影像学上，ARS组的非特异性间质性肺炎（NSIP）模式比非ARS组更常见（73.9% vs. 40%，P = 0.02）。病理上，两组中NSIP最常见。ARS组的10年生存率也显著高于非ARS组（91.6% vs. 58.7%，P = 0.02）。单因素考克斯风险分析显示，抗ARS抗体的存在与较好的预后相关（HR = 0.34，95%CI 0.08-0.80; P = 0.01）。抗ARS抗体的存在是PM/DM-ILD患者的可能预后标志物。
In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established. We aimed to evaluate the clinical significance of anti-ARS antibodies in PM/DM-ILD patients. Forty-eight consecutive PM/DM-ILD patients were studied retrospectively. Anti-ARS antibodies were screened by ELISA and confirmed by RNA immunoprecipitation test. Medical records, high-resolution computed tomography images, and surgical lung biopsy specimens were compared between ARS-positive (ARS group) and ARS-negative patients (non-ARS group). Anti-ARS antibodies were detected in 23 of 48 patients (48%). Radiologically, nonspecific interstitial pneumonia (NSIP) pattern was observed more frequently in the ARS group than in the non-ARS group (73.9% vs. 40%, P = 0.02). Pathologically, NSIP was the most frequent in both groups. Ten-year survival rate was also significantly higher in the ARS group than in the non-ARS group (91.6% vs. 58.7%, P = 0.02). Univariate Cox hazards analysis revealed that the presence of anti-ARS antibodies was associated with better prognosis (HR = 0.34, 95% CI 0.08–0.80; P = 0.01). The presence of anti-ARS antibodies is a possible prognostic marker in patients with PM/DM-ILD.
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影响因子：
24.3
作者：
Cottin, V;Thivolet-Béjui, F;Cordier, JF
通讯作者：
Cordier, JF
影响因子：
--
作者：
Marie, I.;Hatron, P. Y.;Menard, J. -F.
通讯作者：
Menard, J. -F.
DOI：
10.1002/art.10794
发表时间：
2002-12-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Marie, I;Hachulla, E;Courtois, H
通讯作者：
Courtois, H
影响因子：
9.6
作者：
Fischer, Aryeh;West, Sterling G.;du Bois, Roland M.
通讯作者：
du Bois, Roland M.
影响因子：
27.4
作者：
Aggarwal R;Cassidy E;Fertig N;Koontz DC;Lucas M;Ascherman DP;Oddis CV
通讯作者：
Oddis CV