Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.
Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.
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DOI：
10.1002/hbm.25804
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发表时间：
2022-06-15
影响因子：
4.8
通讯作者：
Hoven, Christina W.
中科院分区：
文献类型：
--
作者：
Wang, Zhishun;Rodriguez-Moreno, Diana V.;Cycowicz, Yael M.;Amsel, Lawrence V.;Cheslack-Postava, Keely;He, Xiaofu;Ryan, Megan;Geronazzo-Alman, Lupo;Musa, George J.;Bisaga, Adam;Hoven, Christina W.
关键词：
有研究表明，物质使用障碍(SUD)风险的代际传递表现在物质天真青少年的大脑解剖中。虽然皮质下结构(SSS)的体积和形状被证明是可遗传的，但这些结构，特别是苍白球、壳核、伏隔核和海马体，也与物质使用障碍有关。然而，目前还不清楚这些解剖学上的差异是在物质使用之前还是这种使用的结果。因此，我们检查了有SUD家族史(FH+)的青少年和没有此类病史的青少年(FH−)的体积和SSs是否存在差异。因为SUD的风险与焦虑和冲动有关，我们还检查了这些心理特征和容量/SSS之间的相关性。应用结构磁共振和FSL软件对FH+和58例FH-−青少年的皮质下结构进行分割，得到SSS指数和体积指数。我们考察了群体在音量和SSS上的差异，以及音量/SSS与特质焦虑和冲动的相关性。与FH-−青少年相比，FH+青少年右前海马区的形状有显著的向内变形，而该结构的体积在不同组之间没有差异。其他皮质下结构的形状和体积在不同组之间都没有差异。在FH+青少年中，左侧海马体形状与特质焦虑和冲动均呈正相关，而在FH−青少年中，左侧海马体形状与特质焦虑和冲动呈负相关。SSS似乎捕捉到了传统体积分析所不能捕捉到的局部解剖特征。FH+青少年右侧前海马区向内的形状变形可能与FH+子代行为失调导致SUD的风险增加有关。在FH+和FH−青少年中，海马体形状与焦虑和冲动得分也显示出相反的相关模式。这些新的发现可能揭示了传统容量分析没有捕捉到的神经关联，即家族传播增加了对SUD的易感性。皮质下结构的形状捕捉到了传统体积分析所不能捕捉到的局部解剖特征。有物质使用障碍(SUD)家族史(FH+)的青少年右侧前海马区向内变形可能与FH+子代行为失调导致SUD的风险增加有关。
It has been suggested that intergenerational transmission of risk for substance use disorder (SUD) manifests in the brain anatomy of substance naïve adolescents. While volume and shapes of subcortical structures (SSS) have been shown to be heritable, these structures, especially the pallidum, putamen, nucleus accumbens, and hippocampus, have also been associated with substance use disorders. However, it is not clear if those anatomical differences precede substance use or are the result of that use. Therefore, we examined if volume and SSS of adolescents with a family history (FH+) of SUD differed from adolescents without such a history (FH−). Because risk for SUD is associated with anxiety and impulsivity, we also examined correlations between these psychological characteristics and volume/SSS. Using structural MRI and FSL software, we segmented subcortical structures and obtained indices of SSS and volumes of 64 FH+ and 58 FH− adolescents. We examined group differences in volume and SSS, and the correlations between volume/SSS and trait anxiety and impulsivity. FH+ adolescents had a significant inward deformation in the shape of the right anterior hippocampus compared to FH− adolescents, while the volume of this structure did not differ between groups. Neither shape nor volume of the other subcortical structures differed between groups. In the FH+ adolescents, the left hippocampus shape was positively correlated with both trait anxiety and impulsivity, while in FH− adolescents a negative correlation pattern of SSS was seen in the hippocampus. SSS appears to capture local anatomical features that traditional volumetric analysis does not. The inward shape deformation in the right anterior hippocampus in FH+ adolescents may be related to the known increased risk for behavioral dysregulation leading to SUD in FH+ offspring. Hippocampus shape also exhibits opposite patterns of correlation with anxiety and impulsivity scores across the FH+ and FH− adolescents. These novel findings may reveal neural correlates, not captured by traditional volumetric analysis, of familial transmission of increased vulnerability to SUD. Shapes of subcortical structures capture local anatomical features that traditional volumetric analysis does not. The inward shape deformation in the right anterior hippocampus in the adolescents with a positive family history (FH+) of substance use disorder (SUD) may be related to the known increased risk for behavioral dysregulation leading to SUD in FH+ offspring.
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