Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder.
Subcortical volumes are reduced in short-term and long-term abstinent alcoholics but not those with a comorbid stimulant disorder.
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DOI：
10.1016/j.nicl.2013.06.018
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发表时间：
2013
影响因子：
4.2
通讯作者：
Fein, David
中科院分区：
文献类型：
--
作者：
Fein, George;Fein, David
长期酗酒会影响大脑结构和功能。我们检查了77名短期(每周6-15周)和90名长期(多年)戒酒者的皮质下结构体积，以及74名对照组。我们使用3T西门子MPRAGE序列进行图像采集，使用FSL First软件测量皮质下体积。当检查没有并发兴奋剂障碍的酗酒者时，我们发现短期戒酒的海马体、苍白球和丘脑的体积与非物质滥用对照组相比减少了，数字上较小，但与长期戒酒的对照组相比仍然显著减少。当检查伴有兴奋剂障碍的酗酒者时，没有发现任何皮质下体积与对照组有差异。有兴奋剂障碍的酗酒者比没有兴奋剂障碍的酗酒者皮质下体积大得多。这项研究重复了过去的研究，即长期酗酒与短期戒酒的慢性酒精患者皮质下体积较低有关，并扩展了这一发现，尽管对长期戒酒的样本影响较小。在同时存在兴奋剂障碍的情况下没有这种效应，表明兴奋剂滥用/依赖的保护作用，或者测量反映了酒精依赖相关的萎缩和兴奋剂滥用相关的炎症的总和。与功能的联系暗示了这两种选择中的第二种。皮质下萎缩慢性酒精依赖共病兴奋性障碍
Chronic alcohol abuse affects brain structure and function. We examined subcortical structure volumes in 77 short (6–15 week) and 90 long (multi-year) term abstinent alcoholics, along with 74 controls. We used a 3T Siemens MPRAGE sequence for image acquisition and FSL FIRST software for measuring subcortical volumes. When examining alcoholics without a comorbid stimulant disorder we found reduced hippocampal, pallidum and thalamus volumes in short term abstinence compared to a non-substance abusing control sample with numerically smaller yet still significant reductions compared to controls in long term abstinence. When examining alcoholics with a comorbid stimulant disorder, no difference from controls was found for any subcortical volume. Alcoholics with a stimulant disorder had significantly larger subcortical volumes than alcoholics without a stimulant disorder. This study replicates past research showing that chronic alcohol abuse is associated with lower subcortical volumes in short-term abstinent chronic alcoholics and extends this finding, although with smaller effects to long-term abstinent samples. The absence of this effect in the presence of a comorbid stimulant disorder suggests either a protective effect of stimulant abuse/dependence or that the measurements reflect the aggregate of alcohol dependence associated atrophy and stimulant abuse associated inflammation. Associations with function suggest the second of these two alternatives. Subcortical atrophy Chronic alcohol dependence Comorbid stimulant disorder
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