Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes.
Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes.
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白癜风：发病机制及易感基因的遗传多态性。
DOI：
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发表时间：
2006
影响因子：
0.6
通讯作者：
R. Begum
中科院分区：
文献类型：
--
作者：
E. Shajil;Sreejata Chatterjee;D. Agrawal;T. Bagchi;R. Begum
白癜风是一种由皮肤黑素细胞损失引起的色素脱失疾病，影响世界1-4%的人口。白癜风的发病率在印度为0.5-2.5%，在古吉拉特邦和拉贾斯坦邦的患病率高达8.8%。导致这种疾病中黑素细胞破坏的细胞和分子机制尚未完全阐明。遗传因素、神经因素、毒性ROS代谢产物、自身抗体和自身反应性T淋巴细胞可能是选择性破坏黑素细胞的原因。白癜风发病机制的三大假说是神经假说、自身免疫假说和氧化应激假说，但它们都不能完全解释白癜风的发病机制。白癜风具有遗传不完全多态性、多易感基因位点和遗传异质性等特点。该领域的最新进展是候选基因的连锁和关联研究。连锁和关联研究为不同染色体上存在多个白癜风易感基因提供了强有力的证据。白癜风的几个候选基因从不同的人群中鉴定出来。本文综述了白癜风发病机制的不同假说，并从连锁、关联和候选基因等方面讨论了白癜风发病机制的最新研究进展。
Vitiligo is a depigmenting disorder resulting from the loss of melanocytes in the skin and affects 1-4% of the world population. Incidence of vitiligo is found to be 0.5-2.5% in India with a high prevalence of 8.8% in Gujarat and Rajasthan states. The cellular and molecular mechanisms that lead to melanocyte destruction in this disorder are not yet been fully elucidated. Genetic factors, neural factors, toxic ROS metabolites, autoantibodies and autoreactive T lymphocytes may be the causative agents for the selective destruction of melanocytes. Three major hypotheses of pathogenesis of vitiligo are neural, autoimmune and oxidative stress hypotheses, however none of them explains the pathogenesis of vitiligo in toto. Genetics of vitiligo is characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. Recent advances in this field are linkage and association of candidate gene studies. The linkage and association studies provide a strong evidence for the presence of multiple vitiligo susceptibility genes on different chromosomes. Several candidate genes for vitiligo are identified from different populations. In this review, we have provide an overview of different hypotheses of vitiligo pathogenesis, and discuss the recent advances in this field with special reference to linkage, association and candidate gene approach.
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白癜风抗体定义的色素细胞抗原的鉴定。
DOI：
10.1111/1523-1747.ep12555773
发表时间：
1992
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Cui,J;Harning,R;Henn,M;Bystryn,JC
通讯作者：
Bystryn,JC
影响因子：
--
作者：
Georgia M. Dunston;R. Halder
通讯作者：
Georgia M. Dunston;R. Halder
影响因子：
9.8
作者：
Fain, PR;Gowan, K;Spritz, RA
通讯作者：
Spritz, RA
DOI：
10.1016/s0190-9622(86)70085-6
发表时间：
1986-05-01
影响因子：
13.8
作者：
HALDER, RM;WALTERS, CS;KENNEY, JA
通讯作者：
KENNEY, JA
影响因子：
6.5
作者：
Suzuki, I;Tada, A;AbdelMalek, ZA
通讯作者：
AbdelMalek, ZA