Late cardiovascular consequences of gestational diabetes mellitus.
Late cardiovascular consequences of gestational diabetes mellitus.
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DOI：
10.1055/s-0029-1225260
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发表时间：
2009-07
影响因子：
2.7
通讯作者：
Bentley-Lewis R
中科院分区：
文献类型：
--
作者：
Bentley-Lewis R
妊娠期糖尿病（GDM）定义为妊娠期间首次发现的任何程度的碳水化合物不耐受，在美国约有4%的妊娠并发症。有几个因素可以增加患GDM的风险，包括肥胖、2型糖尿病（T2 DM）家族史和种族/民族。相反，GDM病史不仅会增加T2 DM的风险，还会增加心血管疾病（CVD）的风险，与T2 DM的诊断无关。一些研究已经探索了GDM与CVD危险因素、CVD替代标志物和临床明显CVD的关系。这些研究包括评价生化参数，如炎症和内皮生物标志物;内皮功能障碍，如在受损的肱动脉血流介导的血管舒张中观察到的内皮功能障碍;以及血管功能障碍，表现为心脏功能障碍或高血压等疾病。本文将回顾这些研究，并检查被认为是负责促进有GDM病史的女性CVD的因素，如T2 DM和代谢综合征及其组成部分。此外，将探讨有GDM病史的女性CVD的研究证据。
Gestational diabetes mellitus (GDM), defined as carbohydrate intolerance of any degree first recognized during pregnancy, complicates ~4% of all pregnancies in the United States. Several factors can increase one's risk of developing GDM, including obesity, family history of type 2 diabetes mellitus (T2DM), and race/ethnicity. Conversely, a history of GDM can increase the risk of developing not only T2DM but also cardiovascular disease (CVD) independent of a diagnosis of T2DM. Several investigations have explored GDM relationships with CVD risk factors, CVD surrogate markers, and clinically evident CVD. These studies have included evaluations of biochemical parameters, such as inflammatory and endothelial biomarkers; endothelial dysfunction, such as that seen in impaired brachial artery flow-mediated vasodilation; and vascular dysfunction, manifest as cardiac dysfunction or in diseases such as hypertension. This article will review these studies and examine factors considered to be responsible for promoting CVD in women with a history of GDM, such as T2DM and metabolic syndrome and its components. In addition, studies evidencing CVD in women with a history of GDM will be explored.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/0002-9378(93)90358-p
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