Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.
Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.
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DOI：
10.1186/s13000-016-0554-7
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发表时间：
2016-10-22
影响因子：
2.6
通讯作者：
Nakashima M
中科院分区：
文献类型：
--
作者：
Matsuda K;Tateishi S;Akazawa Y;Kinoshita A;Yoshida S;Morisaki S;Fukushima A;Matsuwaki T;Yoshiura KI;Nakashima M
卵巢有丝分裂活性细胞纤维瘤（MACF）是一种较新的疾病，其特点是有丝分裂活性相对较高，但无严重的异型性。MACF被归类为良性卵巢肿瘤。然而，由于病例报告数量有限，其临床和病理特征以及最佳治疗在很大程度上仍未确定。在此，我们报告一个罕见的MACF病例，其大小迅速增长，并通过详细的病理检查被诊断出来。一名44岁的日本女性，一年前发现子宫肌瘤样病变，随访检查显示肿块增大，转介至我院。磁共振示右侧盆腔T1等强和T2高强度肿瘤（直径11 cm）。腹腔镜检查证实了右侧卵巢肿瘤的存在，并进行了腹腔镜右附件切除术。肿瘤细胞由密集的梭形成纤维细胞样细胞增生组成，无明显的细胞学异型性。有丝分裂活性指数估计为每10个高倍视场有丝分裂15个数字。网状蛋白染色和FOXL2突变分析排除了成人颗粒细胞肿瘤的可能性，患者被诊断为卵巢MACF。据我们所知，我们是第一个在随访期间报告卵巢MACF快速生长的病例。当发现卵巢实性肿块增大时，应考虑MACF作为鉴别诊断。
Mitotically active cellular fibroma (MACF) of the ovary, characterized by relatively high mitotic activity without severe atypia, represents a relatively new disease entity. MACF is categorized as a benign ovarian tumor. However, due to a limited number of case reports, its clinical and pathological features and optimum management remains largely undetermined. Herein, we report on a rare case of MACF that grew rapidly in size and was diagnosed on detailed pathological examination. A 44-year-old Japanese woman, who detected a myoma-like lesion 1-year earlier, was referred to our hospital when the follow-up examination demonstrated that the mass had increased in size. Magnetic resonance imaging revealed a T1 isointense and T2 hyperintense tumor (11 cm in diameter) in the right pelvic cavity. Laparoscopy confirmed the presence of a right ovarian tumor and laparoscopic right adnexectomy was performed. The tumor cells consisted of dense cellular proliferations of spindle fibroblast-like cells without significant cytological atypia. The mitotic activity index was estimated at >15 mitotic figures per 10 high-power fields. Reticulin staining and FOXL2 mutation analysis excluded the possibility of an adult granulosa cell tumor, and the patient was diagnosed with a MACF of the ovary. To the best of our knowledge, we are the first to report on a case of rapid growth of a MACF of the ovary during follow-up. When an increase in the size of a solid ovarian mass is detected, a MACF should be considered as a differential diagnosis.
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影响因子：
4
作者：
Yamada T;Hattori K;Satomi H;Hirose Y;Nakai G;Daimon A;Hayashi A;Terai Y;Ohmichi M;Fukunaga M
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Fukunaga M
影响因子：
158.5
作者：
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影响因子：
7.5
作者：
Kommoss, Stefan;Anglesio, Michael S.;Gilks, C. Blake
通讯作者：
Gilks, C. Blake
影响因子：
1.9
作者：
Bucella D;Limbosch JF;Buxant F;Simon P;Fayt I;Anaf V;Noël JC
通讯作者：
Noël JC
DOI：
10.1111/j.1447-0756.2006.00448.x
发表时间：
2006-10-01
影响因子：
1.6
作者：
Choi, Won-Jun;Ha, Man-Taek;Lee, Jeong-Hee
通讯作者：
Lee, Jeong-Hee