Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone.
Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone.
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男性神经内分泌性腺轴：频繁采样 LH、FSH 和睾酮。
DOI：
10.1152/ajpendo.1988.254.5.e658
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
CrowleyJr,WF
中科院分区：
文献类型：
--
作者：
Spratt,DI;O'Dea,LS;Schoenfeld,D;Butler,J;Rao,PN;CrowleyJr,WF
以往关于正常男性下丘脑-垂体-性腺轴的偶发性激素分泌的研究，由于受试者的队列研究较少或取样技术有限，结果相互矛盾。我们评估了20名正常男性的促性腺激素和睾酮（T）分泌模式，每隔10分钟采集一次血液，测定促黄体生成素（LH）和促卵泡激素（FSH）。还以20分钟间隔分析了10名受试者的T浓度。在正常男性中观察到以前未被重视的促性腺激素和T分泌模式谱。平均LH浓度和平均LH脉冲幅度在个体之间变化四倍。LH脉冲间期从30到480分钟不等（平均119 +/- 32）。结果还表明，在下丘脑或垂体水平的相对不应期。在3名受试者中，观察到LH脉动的夜间显著加重。通过傅立叶分析，LH在群体中观察到日变化（P <0.02）。平均FSH水平显示个体受试者之间存在显著差异，很少观察到离散脉冲。FSH分泌无昼夜变化。受试者之间以6小时间隔测定的血清T浓度范围为105至1，316 ng/dl。当T在20分钟的时间间隔测量，显着的间歇性下降的T浓度水平远低于正常范围内观察到10名受试者中的3。发现T分泌滞后于LH分泌约40 min（P <0.02）。
Previous studies of episodic hormone secretion of the hypothalamic-pituitary-gonadal axis in normal men have produced conflicting results due to examinations of small cohorts of subjects or to limited sampling techniques. We evaluated gonadotropin and testosterone (T) secretory patterns in 20 normal men by sampling blood at 10-min intervals for luteinizing hormone (LH) and follicle-stimulating hormone (FSH). T concentrations were also analyzed at 20-min intervals in 10 subjects. A previously unappreciated spectrum of gonadotropin and T secretory patterns was observed in normal men. Both mean LH concentrations and mean LH pulse amplitudes varied fourfold between individuals. LH interpulse intervals varied from 30 to 480 min (mean 119 +/- 32). Results also suggested a relative refractory period at the level of the hypothalamus or pituitary. In three subjects, a striking nighttime accentuation of LH pulsations was noted. Through use of Fourier analysis, a diurnal variation in LH was observed in the population (P less than 0.02). Mean FSH levels showed marked variation between individual subjects, with discrete pulses rarely observed. No diurnal variation in FSH secretion was noted. Serum T concentrations determined at 6-h intervals ranged from 105 to 1,316 ng/dl between subjects. When T was measured at 20-min intervals, marked intermittent declines in the T concentrations to levels well below the normal range were observed in 3 of 10 subjects. T secretion was found to lag behind LH secretion by approximately 40 min (P less than 0.02).
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影响因子：
5.8
作者：
M. Okamoto;C. Setaishi;K. Nakagawa;Y. Horiuchi;K. Moriya;S. Ito
通讯作者：
S. Ito
影响因子：
15.9
作者：
SANTEN, RJ;BARDIN, CW
通讯作者：
BARDIN, CW
影响因子：
64.8
作者：
C. Faiman;R. Ryan
通讯作者：
R. Ryan
人血清 FSH 和 LH 水平缺乏昼夜周期性。
影响因子：
5.8
作者：
D. Krieger;R. Ossowski;M. Fogel;W. Allen
通讯作者：
W. Allen
DOI：
10.1210/jcem-28-10-1473
发表时间：
1968
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
N. Peterson;A. Midgley;R. Jaffe
通讯作者：
R. Jaffe