Brain-Gut-Microbiome Interactions and Intermittent Fasting in Obesity.
Brain-Gut-Microbiome Interactions and Intermittent Fasting in Obesity.
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脑肠道微生物组相互作用和间歇性禁食肥胖。
DOI：
10.3390/nu13020584
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发表时间：
2021-02-10
期刊：
影响因子：
5.9
通讯作者：
Mayer EA
中科院分区：
文献类型：
--
作者：
Frank J;Gupta A;Osadchiy V;Mayer EA
肥胖流行病及其代谢后果是美国和全球的一个主要公共卫生问题。虽然潜在的原因是多因素的，但脑-肠-微生物组（BGM）系统的失调起着核心作用。正常的饮食行为是由肠道、肠外和中枢内稳态和享乐机制之间严格调节的平衡来协调的，从而导致稳定的体重。通过中枢（多巴胺能信号的破坏）和肠道（迷走神经传入功能、代谢性毒血症、全身免疫激活、肠道微生物组和代谢组的改变）机制，廉价、美味和高热量食物的无处不在的供应和营销，在将这种平衡转向享乐性饮食方面发挥了至关重要的作用。内稳态和享乐性饮食行为之间的平衡不仅受到饮食的数量和组成的影响，还受到食物摄入的时间和节奏的影响。昼夜节律性影响饮食行为和多种肠道功能，以及肠道微生物群的组成和相互作用。据报道，间歇性禁食和限时进食对肠道微生物群和宿主代谢的深刻临床前影响，主要在动物模型和有限数量的对照人体试验中得到证实。在这篇综述中，我们将讨论限时饮食对BGM的影响，并回顾这种饮食模式在肥胖治疗中的前景。
The obesity epidemic and its metabolic consequences are a major public health problem both in the USA and globally. While the underlying causes are multifactorial, dysregulations within the brain–gut–microbiome (BGM) system play a central role. Normal eating behavior is coordinated by the tightly regulated balance between intestinal, extraintestinal and central homeostatic and hedonic mechanisms, resulting in stable body weight. The ubiquitous availability and marketing of inexpensive, highly palatable and calorie-dense food has played a crucial role in shifting this balance towards hedonic eating through both central (disruptions in dopaminergic signaling) and intestinal (vagal afferent function, metabolic toxemia, systemic immune activation, changes to gut microbiome and metabolome) mechanisms. The balance between homeostatic and hedonic eating behaviors is not only influenced by the amount and composition of the diet, but also by the timing and rhythmicity of food ingestion. Circadian rhythmicity affects both eating behavior and multiple gut functions, as well as the composition and interactions of the microbiome with the gut. Profound preclinical effects of intermittent fasting and time restricted eating on the gut microbiome and on host metabolism, mostly demonstrated in animal models and in a limited number of controlled human trials, have been reported. In this Review, we will discuss the effects of time-restricted eating on the BGM and review the promising effects of this eating pattern in obesity treatment.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1016/j.bpg.2014.07.003
发表时间：
2014-08-01
影响因子：
3.2
作者：
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影响因子：
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作者：
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迷走神经的肥胖关键。
影响因子：
8.1
作者：
de Lartigue G;Ronveaux CC;Raybould HE
通讯作者：
Raybould HE
影响因子：
29
作者：
Chaix A;Zarrinpar A;Miu P;Panda S
通讯作者：
Panda S